A particle beam adjustment device includes: a position monitor that detects a positional deviation of a particle beam transported from a beam transport section; an interlock device to interrupt irradiation of the particle beam when a positional deviation of the particle beam is detected by the position monitor; a pair of screen monitors that measure position and angle of an axis of the particle beam; a correction electromagnet that controls the axis of the particle beam by adjusting a magnetic field on a basis of a signal indicating the particle beam position and angle measured by the screen monitors; and a beam scanning electromagnet that irradiates an irradiation target with the particle beam. One of the screen monitors is installed outside a treatment room, and the other screen monitor and the position monitor are installed inside the treatment room.

Disclosed a particle accelerator that accelerates a charged particle beam while circulating the charged particle beam as a circulating beam and outputs some of the circulating beam as an output beam, the particle accelerator including: a first deflection section and a second deflection sections each having a deflection electromagnet; a first straight section, a second straight section, and third straight section each not having the deflection electromagnet; and a control unit, wherein a preceding output deflector of the first straight section deflects some of the circulating beam toward an inner side of a circulating trajectory of the circulating beam to separate the some of the circulating beam as an output beam, wherein a succeeding output deflector of the third straight section deflects the output beam separated from the circulating beam by the preceding output deflector toward an outer side of the circulating trajectory of the circulating beam, and wherein the control unit controls at least the quadrupole electromagnet such that a phase advance of a betatron oscillation of the output beam is 270±45 degrees in a section from the preceding output deflector to the succeeding output deflector.

The invention is directed to a data processing method for determining the consistency of registration of the position of a treatment body part to be treated by radiotherapy with a treatment beam arrangement of at least one position of a treatment beam issued by a treatment device, the treatment body part being a soft tissue part of an anatomical structure of a patient's body and the data processing method being constituted to be executed by a computer and comprising the following steps: g) acquiring CT data comprising predetermined CT information about a position of the treatment body part relative to a bony structure of the patient's body and about a first position of the bony structure relative to the treatment beam arrangement; h) acquiring x-ray data comprising x-ray information about a second position of the bony structure relative to the treatment beam arrangement; i) determining, based on the x-ray data and the CT data, bony structure position first transformation data comprising bony structure position first transformation information about a first transformation between the first position and the second position of the bony structure; j) acquiring CBCT data comprising CBCT information about the position of the treatment body part relative to the treatment beam arrangement or relative to the bony structure; k) determining, based on the CBCT data and the CT data, bony structure position second transformation data comprising bony structure position second transformation information about a second transformation between the first position and a third position of the bony structure relative to the treatment beam arrangement; determining, based on the bony structure position first transformation data and the bony structure position second transformation data, transformation difference data comprising transformation difference information about a difference between the first and second transformations.

A scanning candidate route extracting unit which extracts plural candidates of scanning routes in which each of the scanning routes connects all spot positions in one layer is provided, in an evaluation function using necessary scanning time Tk and weight coefficient wk for a kth partial route among partial routes which are routes between the spot positions which are adjacent on one of the plural candidates of scanning routes, and number n of spot in the layer, wk with respect to a partial route which passes through affected tissue is set to be 1, wk with respect to a partial route which passes through normal tissue is set to be bigger than 1, and wk with respect to a partial route which passes through an important internal organ is set to be bigger than wk with respect to a partial route which passes through normal tissue.

Provided are a method and apparatus for manufacturing a radiation beam intensity modulator. The method includes: obtaining dose modulation information expressed as a density matrix or three-dimensional (3D) structure information provided from a radiotherapy treatment planning system; obtaining design condition information of a radiation beam intensity modulator provided from the radiotherapy treatment planning system; generating a radiation beam intensity modulator structure based on the design condition information of the radiation beam intensity modulator and the dose modulation information expressed as the density matrix or the 3D structure information; adjusting the radiation beam intensity modulator structure by comparing at least one of an actual manufacturing condition and a treatment condition with the design condition information of the radiation beam intensity modulator; and manufacturing the radiation beam intensity modulator based on the radiation beam intensity modulator structure that is adjusted.

A patient supporting device includes: a base; a positioner; a platform having a first end and a second end; and a controller; wherein the positioner is operable by the controller to place the platform at one of a first plurality of possible positions or at one of a second plurality of possible positions, wherein in any of the first plurality of possible positions, the second end of the platform is closer to one of a left side and a right side of a treatment machine; wherein in any of the second plurality of possible positions, the second end of the platform is closer to another one of the left side and the right side; and wherein a size of a first spatial region defined by the first plurality of possible positions is different from a size of a second spatial region defined by the second plurality of possible positions.

A system for treating a patient during radiation therapy is disclosed. The system includes a shell, a plurality of material inserts disposed in the shell, where each material insert of the plurality of material inserts respectively shapes a distribution of a dose delivered to the patient by a respective beam of a plurality of beams emitted from a nozzle of a radiation treatment system, and a scaffold component disposed in the shell that holds the plurality material inserts in place relative to the patient such that each material insert lies on a path of at least one of the beams.

Provided is a technique by which each nuclide is optimized in terms of energy and number of particles and pre-accelerated so as to be injected into a main accelerator in charged particle beam irradiation by the combined use of different nuclides.

A charged particle beam injector includes: a first ion source that generates first nuclide ions; a first linear accelerator that linearly accelerates the generated first nuclide ions to form a first charged particle beam; a second ion source that generates second nuclide ions; a second linear accelerator that linearly accelerates the generated second nuclide ions to form a second charged particle beam; and a switching electromagnet that injects one of the first charged particle beam and the second charged particle beam into an inflector of a main accelerator.

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

A microwave power control device can include: a microwave signal generator and a signal distribution circuitry connected to the microwave signal generator. The microwave signal generator is configured to generate microwave signals and transmit the microwave signals to the signal distribution circuitry; and the signal distribution circuitry is configured to distribute the microwave signals to n accelerating tubes according to a target microwave power distribution ratio, n being an integer greater than or equal to 2.