A tissue treatment catheter and system include a catheter shaft sized and shaped for delivery through a radial artery to a blood vessel of a patient. The catheter shaft has several lumens, including a guidewire lumen, a cable lumen, and one or more fluid lumens. A stiffening web extends from the guidewire lumen and is thicker than an outer wall of the catheter shaft. The tissue treatment catheter and system include an ultrasound transducer, a balloon surrounding the ultrasound transducer, and a single electrical cable electrically connected to the ultrasound transducer to deliver sufficient electrical energy during sonication to the transducer such that the transducer thermally induces modulation of neural fibers surrounding the blood vessel sufficient to improve a measurable physiological parameter corresponding to a diagnosed condition of the patient. Other embodiments are described and claimed.

A medical device and a method of use thereof for frameless stereotaxy guided intracranial surgery. The medical device includes a central section made from a material that is transparent to ultrasound providing a sonic window, and an ultrasound reflective frame surrounding the central section. The method includes the steps of registering the ultrasound reflective frame with the frameless stereotaxy system for localization of the medical device during surgery. The medical device allows use of ultrasound imaging wherein the output of ultrasound imaging can be computationally combined with MRI or CT imaging data to compensate for anatomical changes in brain during surgery and enhanced localization and navigation to the surgery target.

To alleviate information-dependent behavior by using a mobile terminal of a user of the mobile terminal. A mobile terminal including a first signal generator that generates a frequency signal in the audible band, a second signal generator that generates a high-frequency signal in a frequency band higher than the audible band, a speaker that converts the high-frequency signal into a corresponding high-frequency sound, and a timing controller that controls timing of the generation of the high-frequency signal to be a timing that does not correlate with the timing of the generation of the frequency signal in the audible band is provided.

The present invention relates to an ultrasound apparatus for efficiently applying ultrasound waves over a treated area by mechanically moving the ultrasound transducer over an area larger than the Effective Radiating Area (ERA) comprising: (a) an ultrasound transducer, connected by wiring, for dispersing ultrasound waves; (b) an electric actuator for spinning a crank, wherein a shaft is eccentrically attached to said crank for rotatably whirling said transducer in circles.

Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.

An ultrasound transducer assembly is connectable to an ultrasound system and comprises one or more ultrasound transducer elements supported by a cap. The ultrasound transducer elements are operable to direct ultrasound energy toward brain tissue of a subject and/or to receive echo ultrasound energy when the ultrasound transducer assembly is mounted on the head of the subject. Some embodiments include a fillable jacket coupled to the inner surface of the cap and in acoustic contact with the one or more transducer elements.

An ultrasound treatment system operable to deliver ultrasound energy to a patient's brain, the system comprises a treatment ultrasound transducer comprising a plurality of treatment elements, the treatment ultrasound transducer locatable to deliver ultrasound into the head of the patient. The system further comprises a data store, one or more position sensors configured to detect relative movement between the head of the patient and the treatment ultrasound transducer, and a data processor.

Provided herein are methods, systems, and related vectors and compositions allowing for noninvasive control of neural circuits. In particular, the methods and systems herein described utilize acoustically targeted chemogenetics to achieve a noninvasive neuromodulation in specifically selected cell-types among spatially selected brain regions.

A system and method for efficiently transmitting and receiving focused ultrasound through a medium, such as bone, is provided. The focal region of the focused ultrasound is iteratively updated to provide an improved focus through the medium. This method may be carried out using a transducer assembly that includes two or more transmit arrays each operating at a different frequency. An initial focus is set and updated by delivering focused ultrasound with a lower frequency transmit array. The phase corrections determined in the first iteration are applied to subsequently higher frequency transmit arrays and received signals, and the process repeated until a desired focus or image resolution is achieved.

Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject. Other aspects are directed to various related systems and methods of obtaining diagnostic information from, and/or administering therapy to, a subject.