Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.

We provide a novel technique for coupling focused ultrasound into the brain. The ultrasound beam can be used for therapy or neuro-modulation. We excite a selected Lamb wave mode in the skull that mode converts into longitudinal waves in the brain. The benefits of our approach is in improved efficiency, reduction in heating of the skull, and the ability to address regions in the brain that are close or far from the skull.

Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.

Provided is a magnetic resonance imaging (MRI) receiver coil device and methods of manufacture. An MRI receiver coil device comprises a thin-film substrate layer configured in a dome shape and a coil array positioned around a circumference of an exterior surface of the thin-film substrate layer. A thin-film cover layer is positioned over the exterior surface of the thin-film substrate layer such that the coil array is positioned between the thin-film cover layer and the thin-film substrate layer. The MRI receiver coil device further comprises an end ring engaging the thin-film substrate layer and the thin-film cover layer such that a watertight seal is formed around the coil array between the thin-film substrate layer, the thin-film cover layer, and the end ring. The coil array comprises a plurality of coil elements, each coil element comprising a loop of conductive trace material with at least one capacitive segment.

Embodiments are provided that enhance ultrasound efficacy by for example, high efficiency, signal measurement, calibration, and assurance systems with a control system radio-frequency (RE) driver configured to drive one or more focused ultrasound transducers. The RE driver can comprise one or more power amplifiers including one or more III-V semiconductors, (e.g., gallium nitride GaN, GaAs, GaSb, InP, InAs, InSb, InGaAs, AlSb, AlGaAs, and/or AlGaN) field-effect transistors to efficiently provide high power with distinct narrow-band RE signals over a wide frequency range. The RE driver can include a power measurement and/or calibration system to monitor the amplitude and phase of the RE signal output from the power amplifier and estimate the amount of RE power delivered to the ultrasound transducers.

An ultrasound device for facilitating waste clearance of the brain lymphatic system includes: a first frequency-generator generating a predetermined frequency; a first waveform modulator modulating a waveform of the frequency; a first linear amplifier amplifying the waveform; a first resonance circuit portion matching impedance of the amplified waveform; and a first ultrasound transducer coupled to the first resonance circuit portion and irradiating ultrasound toward the area of the brain of mammals, wherein the ultrasound facilitates clearance of lymphatic wastes of the brain.

Methods of improving ARDS by regulating a stellate ganglion is provided herein. Methods of improving a hypercoagulation state are also provided by regulating the sympathetic nervous system.

An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.

Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor; and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation; an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation. Further described are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also describe are computer systems for operating implantable devices, methods of detecting radiation, methods of treating a solid cancer in a subject, and methods of monitoring a subject for recurrence of a solid cancer.

Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.