Provided is a method for treating metastatic disease or any other tumor that cannot easily or readily localized or localized at all using immersion mechanotherapy. The method includes providing a vessel containing an amount of medium for immersing at least a portion of a subject, and applying one or more programmed cycles of ultrasound waves to the subject through the medium for a pre-determined period of time. Also provided is a device for implementing the immersion mechanotherapy.

The invention relates to a method for producing a lens for an ultrasound apparatus, as well as to an apparatus comprising the lens. The method comprises choosing a source point, providing a treatment volume situated inside a bone tissue model, providing a plurality of nodes distributed inside the treatment volume, and simulating the emission of a spherical wave from each of the nodes. Thus, a simulated wave front is created, in which each spherical wave has an amplitude and a phase, there being at least two nodes with different amplitudes and/or phases. The simulated wave front is received on a receiving surface. On the basis of the processed results, a holographic lens surface is designed, which can generate a wave pattern equivalent to the simulated wave.

A lens system for a camera objective has a plurality of optical lenses that are arranged one after another along an optical axis and are configured for imaging in the visually perceivable spectral range. At least a part of the optical lenses has two types of lens faces that intersect a beam path of the camera objective. At least three of said lens faces are provided with a first anti-reflective coating which has a larger reflectance in at least one partial region of the visible spectral range than a second anti-reflective coating of the remaining lens faces. In addition, a camera objective including the lens system and a method for producing a lens system are provided.

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

The present invention relates to an implantable ultrasound (US) generating device for implantation within the vertebral column of a vertebrate subject, wherein the implantable US generating device comprises at least one US generating transducer suitable for emitting US beam(s) with an oblique orientation with respect to a longitudinal axis of a vertebral column.

The present invention generally relates to, inter alia, devices, methods, and systems for use in medical applications for humans and animals involving long duration ultrasound treatment. An ultrasound transducer array is provided that includes (i) a plurality of ultrasound transducers arranged in a matrix formation and operably coupled to an electrical network and (ii) a mesh structure securing the plurality of ultrasound transducers in the matrix formation, where each ultrasound transducer is connected to the electrical network in a manner sufficient to allow each ultrasound transducer to operate independent of one another or in unison. Ultrasound systems including the ultrasound transducer array and methods of using the ultrasound systems are also disclosed.

A high intensity focused ultrasound (HIFU) system (100,400) for selectively sealing a vessel network (360) in a liver includes a generator (110,410,420) configured to generate and supply electric power, and an acoustic assembly (200,130,150) configured to receive the supplied electric power. The acoustic assembly (200,130,150) includes a first transducer (310,430) configured to generate vibrations having a first frequency, and a second transducer (320,440) configured to generate vibrations having a second frequency. When a first focal point of the generated vibrations having the first frequency and a second focal point of the generated vibrations having the second frequency are aligned within a focused region (350), a group of vessels (360) at the focused region (350) are selectively sealed.

The present invention relates to a low-intensity focused ultrasound therapeutic device. According to one aspect of the present invention, provided is a low-intensity focused ultrasound therapeutic device which employs a single element ultrasound transducer having a focal region, a focal distance and output intensity that can be provide safer treatment for the deep brain of a patient.

A wearable ultrasound device and method of using the device includes a power controller with a power source and at least one integrated circuit that delivers electrical power to an applicator. The applicator is electrically coupled to the power controller and a surface of the applicator transmits ultrasound to a wearer for a given duration. The applicator includes radio frequency (RF) drive electronics, an ultrasound transducer coupled to the drive electronics, a monitoring apparatus that includes a thermal cutoff coupled to the drive electronics, where the monitoring apparatus monitors a temperature of the applicator surface and the thermal cutoff turns off the applicator, if the temperature exceeds a pre-defined threshold, and a coupling bandage coupled to the applicator, where the bandage positions the surface of the applicator proximate to a wearer at a location on the body of a wearer.

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.