The tissue removal device using focused ultrasound includes a focused ultrasound output unit, a mode setting unit to set an output mode of the focused ultrasound, and a control unit to control output characteristics of the focused ultrasound according to the set mode, wherein the output mode is selected from a first mode for removing a tissue in a local area using a vapor bubble formed by the focused ultrasound, a second mode for removing a tissue in a narrower area than the first mode by controlling the output characteristics of the focused ultrasound immediately after the vapor bubble is formed by the focused ultrasound, and a third mode for obtaining a skin tightening effect by generating heating in a subcutaneous fat layer using focused ultrasound of lower intensity and a longer pulse length than the first mode and the second mode.

A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

An apparatus comprises a source of ultrasound energy comprising a plurality of ultrasound transducers. Each of the plurality of ultrasound transducers is configured to direct ultrasound energy to a treatment region located at a depth below a skin surface associated with a patient. The apparatus further comprises a control system for controlling power to the plurality of ultrasound transducers and a water circulation system for controlling a temperature associated with the plurality of ultrasound transducers. The apparatus further comprises an imaging transducer for spatially registering the location of the treatment region.

The present disclosure provides an ultrasonic transducer and a focused ultrasound treatment device. The ultrasonic transducer includes a sound generation unit and a sound emitting surface, the sound emitting surface being a spherical surface having a first notch, a second notch and a third notch, wherein one great circle of a sphere corresponding to the sound emitting surface is a main great circle, the first notch and the second notch are respectively positioned at two intersections of the spherical surface and a diameter perpendicular to the main great circle, and the third notch connects the first notch with the second notch; each cross-section of the sound emitting surface parallel to the main great circle is in a shape of an arc; and the ultrasonic wave generated by the sound generation unit is focused on a center of the sphere corresponding to the sound emitting surface.

Methods of using pulsed focused ultrasound (pFUS) therapy to treat pancreatic disorders such as type 1 diabetes, pancreatitis, and pancreatic cancer are provided. The methods utilize pulsed focused ultrasound (pFUS) therapy either by itself or in combination with islet transplantation and/or stem cell therapy to promote regeneration of damaged pancreatic tissue, increase insulin secretion in response to glucose, or improve engraftment and revascularization of transplanted islets or beta cells. Additionally, methods of using pFUS are provided for modulating paracrine secretion in the pancreas, islets, beta cells, or stem cells, or at a transplantation site to therapeutically alter levels of various factors including, without limitation, cytokines, growth factors, angiogenic factors, and cell adhesion molecules.

A handheld focused extracorporeal shock wave therapy (f-ESWT) device includes a plurality of piezoelectric elements, a power supply circuit, and a plurality of driver circuits. The piezoelectric elements are each configured to generate an individual shock wave. The power supply circuit is configured to output a first DC voltage and a second DC voltage. The first DC voltage greater than the second DC voltage. The driver circuits are each operably connected to the first DC voltage, the second DC voltage, and to a corresponding piezoelectric element of the plurality of piezoelectric elements. Each driver circuit includes a switching element electronically configurable in an open state and in a closed state. When the switching element is in the open state, the first DC voltage and the second DC voltage are applied to the corresponding piezoelectric element to pre-charge the corresponding piezoelectric element with a DC pre-charge voltage having a first polarity.

The present invention relates to a portable HIFU skin care device. The portable HIFU skin care device (1) of the present invention is divided into three portions. Firstly, a main body (100) has a rechargeable battery embedded therein, a power button and a step button installed therein for adjusting the intensity of an ultrasonic wave, and a display for displaying the operation states of the device, including the number of shots. In addition, a cartridge (200) is used by being mounted on a head part of the main body (100) and has a HIFU transducer embedded therein. A cradle (300) has a charging part which is installed therein, is capable of charging by being connected with the cartridge (200) and an adaptor, accommodates the main body (100) through a placement groove while the cartridge (200) is mounted to the main body (100), includes a UV lamp for disinfecting the head part of the cartridge (200) when accommodating the main body (100), and charges an internal battery of the main body (100). In an operation state, while the HIFU transducer is linearly moved for each one shot by a piezoelectric motor, a plurality of ultrasonic waves are emitted so as to form a plurality of ultrasonic focal point regions on an object, thereby achieving a skin care effect. In the present invention, the piezoelectric motor (216) is particularly installed inside the cartridge (200).

A transducer array includes at least one annular shear wave generation transducer that defines an interior area, the at least one annular shear wave generation transducer being configured to generate a shear wave excitation to a region of interest such that the shear wave excitation excites at least a part of a corresponding cylindrical portion of the region of interest and shear waves propagating from the cylindrical portion of the region of interest constructively interfere in an interior region of the cylindrical portion of the region of interest; and at least one tracking transducer positioned in the interior area of the at least one annular shear wave generation transducer, the at least one tracking transducer being configured to detect a shear wave in the interior region of the region of interest.

According to a high-intensity focused ultrasonic apparatus and a control method, an image of a region to be treated is obtained by means of an imaging device, a working assembly and a target coordinate point in the region to be treated are located by means of an optical tracking device, so that a positioning device can clamp the working assembly to quickly and accurately move to a working position corresponding to the target coordinate point, thereby enabling the working assembly to quickly and accurately release a high-intensity focused ultrasonic pulse to the target coordinate point, which improves not only the treatment accuracy but also the treatment efficiency of the high-intensity focused ultrasonic apparatus.

Disclosed are systems and methods for focusing ultrasound transducers that include multiple separate, independently movable transducer segments.