A surface cleaning means is proposed based on the combined use of ultrasound and radiofrequency electromagnetic emissions, propagated onto a surface to be cleaned, to provide synergistic cleaning action. One aspect provides a cleaning unit which comprises a body which includes an ultrasound transducer arrangement and an RF emitter arrangement, and wherein the two are arranged such that, when driven by respective drive signals, ultrasonic and RF emissions (for providing a cleaning action) are generated which overlap in a common spatial region, to thereby provide combined cleaning action in the common spatial region. One example application is for use for oral cleaning.

Systems and methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Lifting sagging tissue on a face, neck, and/or body are described. Treatment with heat is provided in several embodiments.

Various embodiments provide a method for an extended field of view treatment. The method can include the steps of imaging a region; targeting a region with directed ultrasound energy; monitoring the region; moving the imaging, treatment, and monitoring region while spatially correlating to one or more prior regions via imaging and/or position sensing; continuing the extended field of view treatment; and, achieving an ultrasound induced biological effect in the extended field of view treatment region.

An ultrasound treatment device (1) which comprises a probe head (2) that comprises an ultrasound transducer (3) and an imaging device (4), a deformable coupling balloon (5) with a cavity (6), between the probe head (2) and the coupling balloon (5) filled with a coupling liquid (7), a pressure sensor (9) for determining the pressure of the coupling liquid (7) in the cavity (6), a fluid control system (10), and a controller unit (13). The device (1) is adapted to switch between at least first and second operating modes (I, II). In the first operating mode (I), the pressure of the coupling liquid (7) is maintained at a first pressure value (P1), and, in the second operating mode (II), the pressure of the coupling liquid (7) is maintained to a second pressure value (P2) which is higher than the first pressure value (P1).

A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.

Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.

An ultrasound apparatus of a body cavity insertable type includes: a handpiece; a supporting rod which is elongated from the handpiece; an ultrasound probe which is connected to the supporting rod and is configured to be able to be inserted in the body cavity; and a sealing cover which is separably coupled to the ultrasound probe to at least partially surround the ultrasound probe in a longitudinal direction from a distal end thereof. The ultrasound probe includes: a piezoelectric element; and a housing to which the piezoelectric element is mounted. An end of the housing is connected to the supporting, and the housing is provided with an ultrasound passing hole which is disposed outside the supporting rod. The sealing cover has an ultrasound passing window which is formed at a position corresponding to the ultrasound passing hole.

A method for using metastable perfluorocarbon nanodroplets for ultrasonic lysis of blood clots includes administering metastable perfluorocarbon nanodroplets into a blood vessel that includes or that leads to a blood vessel that includes a blood clot, the metastable perfluorocarbon nanodroplets each have a liquid core comprising a perfluorocarbon material that has a boiling point below 25 C. at atmospheric pressure and that remains stable in liquid form at 25 C. at atmospheric pressure. The method further includes applying ultrasound energy to the perfluorocarbon nanodroplets within or surrounding the blood clot, causing the perfluorocarbon nanodroplets to vaporize and convert to bubbles, which cavitate and lyse the blood clot.

A controller changes a position and/or orientation of a treatment head by controlling an operation of a robot arm according to an external input. A probe driver changes a projection amount of a diagnostic probe with respect to an irradiator. Further, the controller performs synchronous control to synchronize the probe driver and the robot arm with each other so that the relative position between the irradiator and the distal end of the diagnostic probe changes while holding the distal end position of the diagnostic probe.

Systems and methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Lifting sagging tissue on a face, neck, and/or body are described. Treatment with heat is provided in several embodiments.