A support structure for placement on or about a subject's head supports an ultrasound transducer array configured to deliver transcranial stimulation to a specified region or regions of the subject's brain using pre-recorded neurostimulation data. The pre-recorded neurostimulation data comprises patterns of stimulation of the specified region or regions of the subject's brain or other person's brain developed to recreate a response by one or more of a sensing organ or sensing organs, a vestibular system, and a memory of the subject. A magnetic sensor array is mounted to the support structure and configured to transcranially sense local magnetic fields emanating from the specified region or regions of the subject's brain caused by delivery of the transcranial stimulation and produce contemporaneous neurostimulation data developed using the transcranially sensed local magnetic fields. Electronic circuitry comprising a controller is configured to control operation of the respective arrays.

A method for cell stimulation by mechanical energy as well as a method for determining a subject specific set of treatment parameters for acoustic wave stimulation and a method for validating a set of treatment parameters for acoustic wave stimulation. The method for determining a subject specific set of treatment parameters includes generating subject specific data, which includes measuring a geometric property of a body portion, and determining a target field distribution in the body portion. The method for validating a set of treatment parameters for acoustic wave stimulation includes determining a target field distribution of an acoustic field in a body portion, receiving a related set of treatment parameters for at least one transducer, generating a subject specific 3D model of the body portion, and determining a difference between the target field distribution and a field distribution determined in the subject specific 3D model.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

A system for treating fat tissue, including: an ultrasound applicator, including: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue; a control unit, including: a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

A high intensity focused ultrasound (HIFU) system (100,400) for selectively sealing a vessel network (360) in a liver includes a generator (110,410,420) configured to generate and supply electric power, and an acoustic assembly (200,130,150) configured to receive the supplied electric power. The acoustic assembly (200,130,150) includes a first transducer (310,430) configured to generate vibrations having a first frequency, and a second transducer (320,440) configured to generate vibrations having a second frequency. When a first focal point of the generated vibrations having the first frequency and a second focal point of the generated vibrations having the second frequency are aligned within a focused region (350), a group of vessels (360) at the focused region (350) are selectively sealed.

Various approaches for regulating microbubbles in a treatment procedure for a target include generating a tissue-sensitivity map including multiple regions, at least one of the regions being outside the target region, the tissue-sensitivity map assigning, to each of the regions, a sensitivity level indicative of tissue sensitivity to the interaction between the microbubbles and an acoustic beam; select one or more interaction regions based at least in part on the tissue-sensitivity map; and activating the ultrasound transducer so as to generate the acoustic beam for interacting with the microbubbles in the selection interaction region(s) in the tissue-sensitivity map, thereby indirectly changing a characteristic of the microbubbles at the target region.

A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.