Various devices related to a therapeutic ultrasound device for use during a medical procedure to cauterize tissue are disclosed. The therapeutic ultrasound device can include an inner tube assembly and an outer tube assembly. The device can further include a tissue engagement assembly that is secured to the distal end of the inner tube and the distal end of the outer tube. The tissue engagement assembly includes a plurality of transducers configured to provide therapeutic ultrasound. The device can include a housing assembly that is secured to the proximal end of the inner tube and the proximal end of the outer tube. The housing assembly can include a handle configured to actuate the inner tube relative to the outer tube to engage and disengage the tissue engagement assembly.

Apparatus and methods for determining positioning of a energy delivery element include deploying a energy delivery element at a treatment site proximal to a vessel wall; using a multi-region pressure sensing apparatus to sense pressures applied in a plurality of directions about the energy delivery element; and determining an orientation of the energy delivery element based on the pressures measured in the plurality of directions about the energy delivery element.

Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may be useful in the treatment of infertility associated with PCOS.

The present technology is directed generally to devices, systems, and methods for capturing and cutting fibrous and trabeculated structures (such as synechiae) in vessel lumens. In one embodiment, the present technology includes an intraluminal tissue modifying system configured to capture the fibrous structures, put the fibrous structures in tension, and controllably cut through the fibrous structures without applying appreciable additional force to the vessel wall. The system may include an expandable capture device and a cutting device.

Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.

A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints.

Apparatus and methods for creating tissue necrosis include an energy delivery apparatus that can be positioned adjacent a target treatment site such as a vessel without direct contact with the treatment site tissue. Collimated energy is then directed to the vessel to create necrotic regions in the tissue. Exemplary use in renal vessels creates necrotic regions in adjacent nerves which can alleviate hypertension in a patient.

Systems for nerve and tissue modulation are disclosed. An illustrative system may include an intravascular nerve modulation system including a catheter shaft, a first flexible mount, and a cylindrical ablation transducer. The ablation transducer may be affixed to the catheter shaft through the flexible mount to allow an infusion fluid to pass through a lumen of the transducer. Another illustrative system may include an intravascular nerve modulation system including an expandable basket for centering an ablation tra7nsducer within a lumen.

A system, method, and storage device storing computer executable instructions for use in tissue analysis and therapy. A motorized optical probe for illuminating tissue generates light fluorescence and/or diffuse reflectance signals corresponding to the illuminated tissue. One or more ultrasound, CT and MRI imaging guidance systems identify the position of the optical probes relative to the tissue. An imaging system generates a three-dimensional image of the tissue based on the generated light signals and the identified position of the optical probe.

A method for delivering therapeutic ultrasound to a patient to ensure full treatment of targeted tissue can include performing preoperative imaging of a first volume of targeted tissue of a patient using an ultrasound probe and creating a first treatment plan. Energy can be delivered into at least a distal portion of the first volume. The amount of energy delivered can be sufficient to produce swelling of tissue in the first volume. The first volume can be reimaged to identify if any changes have occurred in at least one of a size, shape and location of the first volume of the targeted tissue. A second treatment plan can be designed to treat a second volume of tissue equivalent to the changed first volume of targeted tissue. Energy can be delivered into the second volume of the targeted tissue.