Devices and methods that provide minimally-invasive approaches to performing treatments on soft tissue, such as that found in the bladder using various natural access paths such as transvaginal and transurethral. Treatments include the application of energy to nerves found in, under and around the trigone region of the bladder.

Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue.

Surgical systems and methods for administering an ablation treatment and other therapeutic or diagnostic protocols to a patient tissue involve a flexible stabilizer mechanism having an inner recess and an ablation mechanism coupled with the stabilizer mechanism.

Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue.

Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

Provided are products of manufacture and methods for the removal and/or destruction of a biofilm in situ, e.g., a gastro-luminal biofilm, and for the treatment or amelioration of biofilm-associated diseases, infections and conditions, including and GI luminal infections. Provided are devices and apparatus, and methods for using them, for the removal, disruption and/or destruction of a biofilm in situ, e.g., a gastro-luminal biofilm. In alternative embodiments, provided are devices and apparatus, and methods, for enhancing biofilm dissolving or disrupting agents, or for administering biofilm dissolving or disrupting agents, where in alternative embodiments the biofilm comprises a gastro-luminal ‘unstirred layer’, adherent layer or gastro-luminal mucus layer; or the biofilm comprises a matrix or a DNA-containing layer, or alternatively the biofilm comprises a polysaccharide gastro-luminal peripheral layer.

A multi-angular ultrasound device. Multi-angular ablation patterns are achieved by a catheter-based ultrasound transducer having a plurality of transducer zones. A multi-chambered balloon is positioned on the catheter.

A device for treating the prostate and hemorrhoids is proposed, the device including: an anal insertion part including a body module including a first rechargeable battery charged when DC power is applied therein, a first wireless communication device wirelessly transmitting and receiving an electric signal, and an output circuit outputting a current according to the electric signal output from the first wireless communication device, a plurality of electrodes provided in a direction perpendicular to the body module and installed apart along a longitudinal direction on an outer circumferential surface to receive the current applied thereto, and a probe module including a vibrating element installed therein to generate vibration when the current is applied, a heating element generating heat, and a magnet installed at an upper end therein to generate a magnetic force; and a controller provided with a second rechargeable battery, a second wireless communication device, and a control module.

At a distal portion of a shaft of a guide portion included in a medical device, a first portion is configured to be capable of coming into contact with an inner wall of a living organ. A second portion is disposed on a proximal side of the shaft with respect to the first portion. The second position is configured to be capable of coming into contact with the inner wall of the living organ at a position different from that of the first portion on a transverse cross section of the inner wall of the living organ. A treatment portion is movable in a lumen of the shaft in a state where at least a part of the first portion and at least a part of the second portion come into contact with the inner wall of the living organ.