Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.

A method is provided for treating neurogenic anorexia nervosa in a subject in need thereof, using a magnetic resonance guided focused ultrasound treatment system. The method comprises applying high-intensity focused ultrasound energy to multiple treatment target points on the bilateral anterior limbs of the left and right internal capsules of the subject to regulate the bilateral anterior limbs of the subject; and inducing normalization of weight in the subject.

A method for fractional ultrasonic treatment with a uniform coverage of a skin treatment area includes: using a first focused ultrasonic energy to create a regularly arranged set of focuses into the skin treatment area; and using a second focused ultrasonic energy to create an irregularly arranged set of focuses into the skin treatment area.

There is provided in accordance with an exemplary embodiment of the invention a method and/or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and/or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and/or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and/or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.