The invention relates to valve system for controlling a process fluid within a liquid processing system. The valve system comprises a valve arrangement, a pneumatic control system, and a connector unit. When the valve arrangement is connected to the connector unit, two or more valves are formed, such that the pneumatic control system controls an open/close or pressure control mode of the valves. A pump diaphragm system is disclosed, as well as a system for purifying a biological material that comprises the valve system or the pump diaphragm system. Also discloses are methods of using the valve system or the pump diaphragm system in a process for the purification of a biological material.

A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.

A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.

A diaphragm pump includes a transfer chamber containing hydraulic fluid and a pumping chamber for fluid to be pumped. A connecting assembly includes a plunger extending to the transfer chamber. A diaphragm connects to the connecting assembly and separates the transfer chamber and the pumping chamber. A pressure protection device mounts to the connecting assembly and is configured to seal against the transfer chamber when pressure differential, including reverse pressure differential, across the diaphragm exceeds a predetermined value. The pressure protection device is intermediate the plunger and the diaphragm and supports the diaphragm when there is excess pressure differential across the diaphragm.

Various systems and methods for detecting air in a chamber of an infusion system are disclosed. In one embodiment, a determination is made that air is contained in the chamber on the basis of a change in the average force exerted against the plunger utilizing a derivative spike for event detection and a systematic reduction in the average force to confirm the nature of the change. In another embodiment, a determination is made that the chamber contains air when a difference between the current force profile and a baseline force profile crosses a threshold. In an additional embodiment, a force profile is classified as being an air force profile or a liquid force profile based on extracted features of the force profile.

A hose pump rotor includes a main rotating shaft. The main rotating shaft includes a main shaft and a rotor base which are fixedly connected to each other, roller support arms are symmetrically arranged on the rotor base and outer ends thereof are connected to rollers, with axes of the rollers being parallel to an axis of the main shaft, the roller support arms and the rotor base form a radially-displaceable limiting fit, and the roller support arms and the rotor base form a locking fit. The rotor base includes a groove enclosed by a bottom plate and side plates disposed on opposite sides thereof, wherein the bottom plate is fixedly connected to the main shaft.

A pump assembly includes a housing having two parts with internal cylindrical chambers having openings for the inlet and outlet of a pumped fluid, and two longitudinally deformable bellows fastened inside the respective parts of the housing. The opposite end of each bellows has a plug. On the end surface of the housing the bellows are connected to is an opening for the inlet of a working fluid into the corresponding internal chamber. A hydraulic system for controlling the pump assembly includes a tank containing a working fluid, a positive displacement pump, two independent hydraulic pipelines, and a system of valves for alternately connecting the bellows' internal chambers containing working fluid to the pipelines. The internal chamber of each bellows is alternatingly connected to the positive displacement pump for supplying working fluid by a first hydraulic pipeline and to the working fluid tank by a second hydraulic pipeline.

A diaphragm unit for a diaphragm pump includes a diaphragm core and a multi-layer pump diaphragm connected to the diaphragm core. The pump diaphragm has a fluid-impermeable working layer which comes into contact with a fluid to be delivered, and a fluid-impermeable safety layer. A sealed volume for receiving fluid passing through the working layer is arranged between the working layer and the safety layer. A first clamping region of the diaphragm forms a ring which annularly surrounds the diaphragm core. To detect a rupture of the working diaphragm layer, at least one element of a sensor is provided within the ring formed by the first clamping region for detecting fluid which penetrates into the sealed volume.

Aspects are provided for pumps and methods and systems for controlling pumps based on a bubble sensor. A pump system includes a drive motor, a pump head that receives tubing, and a controller configured to control a rotation of the drive motor to move a liquid within the tubing from an inlet to an outlet. The bubble sensor is coupled to the tubing downstream from the outlet and configured to send a signal to the controller in response to presence of a gas bubble within the tubing. The controller is configured to: determine a quantity of bubbles detected based on the signal; determine an alert in response to the quantity of bubbles detected exceeding a threshold; and stop the drive motor after a safe operating time from the alert. The threshold and the safe operating time are based, at least in part, on a characteristic of the tubing.

A pulsatile fluid pump system includes a pump-valving assembly including a chamber and a diaphragm assembly coupled to the chamber and including a flexible diaphragm. The diaphragm assembly and the pump-valving assembly are configured as an integral pump assembly. The system further includes a linear motor having a magnet and a coil, the magnet moving in relation to the coil, the coil having an electrical input. The system also includes a control housing rigidly coupled to the linear motor and a controller system having an electrical output coupled to the electrical input of the coil, the controller system defining an electrical waveform at the electrical output to cause desired operation of the diaphragm. The integral pump assembly is configured to be removably coupled to the control housing, and the diaphragm assembly of the integral pump assembly is configured to be removably coupled to the linear motor.