An aseptic low-temperature coupling assembly includes a first connector, a second connector, and a gasket disposed in the first or the second connector. The first and second connectors include a first retaining feature and a second retaining feature configured to couple together the first and the second connectors and align openings in the first and second connectors. The gasket is formed to have no substantial deformation after being cooled to at least −50° C. then heated to ambient temperature. A method of aseptically connecting a low-temperature fluid storage container includes coupling a first connector to a second connector via first retaining features and second retaining features of the connectors. The coupling compresses a gasket between the first connector and the second connector and aligns an opening in the first connector with an opening in the second connector.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, aseptic disconnection functionality that substantially prevents fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, aseptic disconnection functionality that substantially prevents fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

This document describes aseptic fluid coupling devices for fluid systems and methods of manufacturing such aseptic fluid coupling devices. For example, this document describes aseptic fluid coupling devices that include removable membrane strips that protect the interior of the aseptic fluid coupling devices from contamination prior to use. Methods for attaching removable membranes to the aseptic fluid coupling devices are also described.

A clamp comprising: a first arcuate portion; a second arcuate portion hingedly connected to the first arcuate portion; and a ratchet mechanism for locking the first and second arcuate portions in a closed position; wherein the ratchet mechanism comprises a linear rack provided with the second arcuate portion and a pawl provided with the first arcuate portion for receiving the linear rack; wherein the linear rack comprises one or more asymmetrical teeth; wherein the pawl comprises a plurality of fingers which are biased into engagement with the teeth of the linear rack.

A connection clamping device comprising two halves which are arranged to be connected and locked to each other by a locking mechanism around the a flexible tube, such that the flexible tube is compressed by a rib provided on the inner circumference of the connection clamping device.

The invention relates to a sterile connector for the sterile transfer of a liquid medium, in particular a biological medium, from a liquid container (2) into a fluid chamber (3, 3), wherein the sterile connector (1) has a first coupling device (5) and a second coupling device (6). It is proposed that the first coupling device (5) has a fluid inlet (7) and a fluid outlet (8) and also a first cannula (9), the latter having an end which is directed away from the fluid inlet (7) and forms the fluid outlet (8), that the second coupling device (6) has a fluid passage (10) which, in an initial state of the sterile connector (1), is covered axially by a first septum (11), that the fluid outlet (8), in the initial state of the sterile connector (1), is arranged in a hermetically sealed region of the first coupling device (5) and the surface (11a) of the first septum (11) facing axially away from the fluid passage (10) is arranged in a hermetically sealed region of the second coupling device (6), and that, in a fluidic connection process starting from the initial state of the sterile connector (1), a fluidic connection between the fluid inlet (7) and the fluid passage (10) can be produced by the fact that the end of the first cannula (9) forming the fluid outlet (8) pierces the first septum (11) of the second coupling device (6).

An adapter configured to allow interconnection of a device input connector (DIC) having a first connector configuration and an consumable end connector (CEC) having a second connector configuration, the adapter including a first end having a first connector mateable with the DIC, a second end configured to receive at least part of the CEC, a locking mechanism configured to lock the CEC to the adapter, and a release mechanism configured to release the CEC from the adapter.

This document describes fluid coupling devices for fluid systems and methods of using the fluid coupling devices. Some fluid coupling devices described herein are configured for use in fluid systems for the purpose of providing a sterile connection. Such a sterile connection can be useful for the delivery and/or processing of therapeutic agents, or ingredients thereof, and other purposes.

This document describes aseptic fluid coupling devices for fluid systems and methods of manufacturing such aseptic fluid coupling devices. For example, this document describes aseptic fluid coupling devices that include removable membrane strips that protect the interior of the aseptic fluid coupling devices from contamination prior to use. Methods for attaching removable membranes to the aseptic fluid coupling devices are also described.