A syringe for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe is designed in such a manner that it is ensured that substantially all of the mixed drug is ejected, and in such a manner that an active pharmaceutical ingredient can be lyophilized directly into the syringe. The syringe comprises a syringe body, a first plunger arranged movably inside the syringe body and a second plunger arranged movably inside the first plunger. In one aspect the second plunger comprises a first plunger part and a second plunger part, and the first and second plunger parts are adapted to cooperate to collapse the cavity of the first plunger. In a second aspect the cavity of the first plunger has a first diameter at a distal end and a second diameter at a proximal end, the first diameter being smaller than the second diameter.

An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

A hand-held skin treatment device comprises a source of electromagnetic radiation, an energy supply electrically coupled to the source and a controller arranged to control the energy supplied to the source of electromagnetic radiation. The source, the energy supply and the controller are enclosed in a watertight housing allowing use of the hand-held skin treatment device in a wet environment. To provide sufficient cooling of the source, the device comprises an internal heat exchanger in heat conducting relation with the source, an external heat exchanger outside of the watertight housing, and a heat path from the internal heat exchanger to the external heat exchanger that passes hermetically through a wall of the watertight housing. With this device, users can conveniently integrate their skin treatment activities with the daily washing routine in a shower or bath. The device is especially useful in the context of hair removal.

A ligating system having a ligating apparatus configured to attach to a distal end of a scope and to hold a ligating band thereon; an activating cord configured to extend down a working channel of the scope and attach to the ligating apparatus; and a line pulling assembly including: a central body; an attachment mechanism on the central body configured to attach the line pulling assembly to a proximal end of the scope; an access channel through the central body and in communication with the working channel of the scope, the access channel providing an open inlet to the working channel of the scope when the line pulling assembly is attached to the proximal end of the scope; and a winding mechanism attached to the central body, wherein the winding mechanism is configured to pull the activating cord proximally such that the ligating band is removed from the ligating apparatus.

Disclosed is a flexible plastic hose (1) comprising a tubular hose body (2) having web portions (7) and a helical reinforcing rib (8), and a cuff (3a) mounted to an extremity (16) of the hose body (2) comprising a molded end fitting (5a) bonded to the extremity (16a), and a stress relief element (4) with a first segment (S1) having an internal screw-thread (15) complementary to the helical reinforcing rib (8). Disclosed is also a method for making same, and use of the hose (1) as a medical hose.

Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with the capability of switching between a modelocked pulse operating mode and an amplification operating mode. The operating modes are carried out through the application of a time-dependent bias voltage, having waveforms as described herein, to an electro-optical device positioned along the optical axis of the resonator.

An oral care implement, such as a toothbrush, which includes a handle and a replacement head utilizing a specially designed structure for coupling the replacement head to the handle of the oral care implement. The replacement head comprises a head and a tubular sleeve comprising a cavity for receiving a handle. A protuberance protrudes radially inward from an inner surface of the tubular sleeve for engaging a boss of a stem on the handle to impede rotation of the tubular sleeve about the stem in a first angular direction. A locking tab protrudes radially inward from the inner surface of the tubular sleeve for engaging an undercut surface of the boss to prevent axial disengagement of the tubular sleeve from the stem. The locking tab is circumferentially spaced from the protuberance so that a first axial channel exists therebetween for receiving a section of the boss.

A surgical instrument arrangement has a modular motor drive unit which has a drive arrangement having at least one output element, an instrument shaft that can be detachably connected to the drive unit, and a drive arrangement having at least one input drive element. The output drive arrangement and the input drive arrangement can be coupled to each other by a mechanical interface that has at least one single-sided linkage, a pin, and a cut-out, wherein the pin can be radially expanded in the cut-out. Alternatively, a gap may be formed between the pin and the cut-out, which gap is wavy in the radial direction, and in which a radially displaceable, axially fixed intermediate element arrangement is arranged. The surgical instrument arrangement may also include a sterile barrier, which is provided to envelop the drive unit and to be arranged between the drive unit and the instrument shaft.

A tool for implementing a correction plan in an external fixation frame having a plurality of adjustment elements or screws, for example, generally includes a driver, a motor, a controller, and a processor. The driver is adapted to engage and rotate each of the screws. The motor is coupled the driver and adapted to rotate the driver. The controller is connected to the motor and configured to control operation of the motor. The a processor adapted configured to: receive correction plan data; receive identification data including information for identifying at least one of the plurality of screws; determine movement of at least one of the plurality of the screws based on the correction plan data and the identification data; and send signals indicative of the determined movement to the controller in order to rotate at least one of the plurality of screws according to a predetermined correction plan.

A haptic combination comprising at least one optical element adapted to provide at least two optical functions including provision of a fixed optical power and provision of variable optical power. The haptic combination comprises at least a first haptic adapted to provide anchoring and positioning of at least one of the optical elements and at least a second haptic adapted to provide transfer of movement from at least one driving means in the eye to at least one of the optical elements. Movement of the second haptic is independent from movement of the first haptic.