A non-freezing refrigerated storage liquid for stem cells such as iPS cells, according to an embodiment, comprises: potassium ion species in a range of 30 to 80 mmoL/L; sodium ion species in a range of 30 to 80 mmoL/L, wherein ion-based molar ratio of sodium ion species to potassium ion species (ratio ofNa.sup.+ to K.sup.+) is in a range of 0.5 to 1.3; trolox or its analog at a concentration of 1 to 8 mM; adenine or a salt or derivative thereof at a concentration of 0.1 to 4.2 mM; all of or all but one, two or three of essential amino acids, total content of which is 50 to 200 mg; and non-essential amino acids, total content of which is 50 to 200 mg/L.

The disclosure is a medical device system that applies pressure to biologic products in a container to inactivate pathogens (e.g., viruses, bacteria, including sepsis, fungi, parasites, prions, mold and other harmful microorganisms), or abnormal or damaged cells (e.g., cancer, carcinoma in situ, lipoproteins, lipids, antibodies), while preserving the desired cells and the efficacy of the biologic product (e.g., whole blood, plasma, red blood cells, platelets and cells derived from blood, bone marrow, stem cells, brain dura matter, bone graft, skin graft or other bodily sources, either allogeneic or autologous). The biologic product may be autologously sourced then processed and transfused or administered, or be allogeneicly sourced and then processed and transfused or administered.

Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application.

A repaired ex vivo organ suitable for transplantation in a human, said repaired ex vivo organ having undergone ex vivo organ perfusion for a maintenance period, wherein said organ had been assessed as being unsuitable for transplantation into a human before the maintenance period and was determined to be suitable for transplantation after the maintenance period.

Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.

A simple, natural method of preserving organisms includes sealing biological blood or organisms in a shell filled with resin, curing the resin, and solidifying the shell for a long time to form amber. The biological blood or organisms can be preserved for a long time. Scholars of later generations may research the integrity of the biological blood or organisms of the present days. Otherwise, the biological blood or organisms may be of no researching meaning and purposes due to pollution or oxidation and dehydration. The organisms of the present days may be reconstructed after 100 years by using technologies of that time. Thus, the organisms being extinct due to pollution can be reconstructed. Diversities of organisms on the earth can be maintained. Precious genes of the organisms of the present days can be preserved for thousands years. It contributes greatly to the study of evolution of organisms.

Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: ##STR00001## wherein R.sup.1, R.sup.2, and R.sup.3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH.sub.3).sub.3NO. The formulation is useful for vaccine stabilization.

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.

The present invention relates to a device for cryopreservation of a cell or tissue, including a deposition part on which a cell or tissue is to be deposited, the deposition part having a layer containing a water-soluble polymeric compound on an outermost surface of the deposition part; and a method of cryopreservation using the device.

Provided is an agent for preserving a biological component, comprising a hydrogel, the hydrogel comprising a crosslinked product formed from a compound having a plurality of hydroxyl groups and a modified hyaluronic acid having substituents capable of reacting with the hydroxyl groups to form a crosslinked structure.