The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

A process for recovering solid waste from produced water in an oil sands system utilizing a fluidized bed, comprising: transferring an amount of produced water into a solution tank, producing an enriched salt solution in the solution tank, transferring the enriched salt solution using at least one spray nozzle into a fluidized bed of a fluidized bed spray granulator, heating the fluidized bed with a gas, growing granules within the fluidized bed through evaporative drying of salt from the enriched salt solution, extracting the granules from the fluidized bed spray granulator to produce a granulator product, separating at least a portion of the granulator product into at least two fractions, and removing at least a portion of at least one of the at least two fractions from the system as solid waste brine product.

A process for recovering solid waste from produced water in an oil sands system utilizing a fluidized bed, comprising: transferring an amount of produced water into a solution tank, producing an enriched salt solution in the solution tank, transferring the enriched salt solution using at least one spray nozzle into a fluidized bed of a fluidized bed spray granulator, heating the fluidized bed with a gas, growing granules within the fluidized bed through evaporative drying of salt from the enriched salt solution, extracting the granules from the fluidized bed spray granulator to produce a granulator product, separating at least a portion of the granulator product into at least two fractions, and removing at least a portion of at least one of the at least two fractions from the system as solid waste brine product.

An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

The present invention relates to an improved method for drying microorganisms, especially lactic acid bacteria, in a spray dryer.

The present invention relates to an improved method for drying microorganisms, especially lactic acid bacteria, in a spray dryer.

A spray dried non-hydrogen bonded (NHB) nano-fibrillated cellulose (NFC) composition and methods for preparing such composition are disclosed. The spray dried NFC with a NHB effect results in low packing density.

A spray dried non-hydrogen bonded (NHB) nano-fibrillated cellulose (NFC) composition and methods for preparing such composition are disclosed. The spray dried NFC with a NHB effect results in low packing density.