Systems for monitoring fluid flow in an extracorporeal blood circuit are described. The blood circuit of such systems can include plod pump having a pumping chamber of the blood pump separated from a control chamber of the blood pump by a flexible diaphragm. The control chamber can be configured to transmit positive or negative pressure to operate the diaphragm. The system can include a pressure sensor configured to measure pressure in the control chamber of the blood pump, and a controller configured to receive information from the pressure sensor and to control the delivery of pressure to the control chamber of the blood pump. The controller can also be configured to cause the application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor. When so configured, such controller can transmit a value representing a magnitude of the measured pressure variation to a display associated with the extracorporeal blood circuit.

A reciprocating pump includes: a pump head having an inner space; a diaphragm configured to partition the inner space of the pump head into a pump chamber into which a transfer fluid is to be introduced and a working chamber into which working air is to be introduced; a driving device including a reciprocating member coupled to the diaphragm, the driving device being capable of driving the reciprocating member with the working air at least in a direction that the diaphragm is retracted; and a working air switching device.

A system is provided. The system includes one or more of a first bellows assembly, which includes a first bellows block, a second bellows block, a first pumping bellow, and first and second seals. The first bellows assembly includes a master fluid inlet port configured to receive a fluid and route the fluid to a first coupling. The second bellows block includes a master fluid outlet port and configured to route the fluid in a pressurized state from a second coupling to the master fluid outlet port. The first pumping bellow includes first and second bellow ports, the first pumping bellow oriented between the first and second couplings and coupled to a pump configured to pressurize the fluid. The first seal is disposed between the first coupling and the first bellow port and the second seal is disposed between the second coupling and the second bellow port.

Membranes are provided to be specially developed for use in chambers for artificial circulatory assistance which may be employed primarily in cardiovascular procedures, notably to produce arterial capacitance, to regulate blood pressure, to produce aortic counterpulsation and to pump blood. The membrane may have circular sections that may vary in size or not depending on the function to be performed and are interconnected so that the transition between one section and the other is smooth, regardless of the size of each section. Further, chambers and pumps may be used for cardiopulmonary bypass and a pumping system.

A hemodialysis apparatus comprising diaphragm pumps for the movement of both dialysate and blood, and under the control of a controller, is capable of detecting blood flow conditions that give rise to an alarm and implement procedures to adjust, pause, or halt the pumping of dialysate and/or blood. The controller can direct the application of a time-varying pressure to fluid in the control chamber of a blood pump, and monitor the resulting pressure waveform during a fill stroke of the blood pump. A deviation of the measured pressure variation from an expected value can give rise to an alert to a user and to the initiation of an adjustment, pause, or cessation of the dialysate pump's activity.

A reciprocating fluid pump includes a pump body, a subject fluid chamber, a first plunger located within the subject fluid chamber of the pump body and having a first head portion and a first bellows, the first plunger configured to expand and compress in a reciprocating action to pump the subject fluid through the subject fluid chamber within the pump body, wherein the first head portion and the first bellows have a first cross-sectional dimension, and a second plunger located within the subject fluid chamber of the pump body and having a second head portion and a second bellows, the second plunger configured to expand and compress in a reciprocating action to pump the subject fluid through the subject fluid chamber within the pump body, wherein the second head portion and the second bellows have a second cross-sectional dimension that is smaller than the first cross-sectional dimension.

An electronically controlled diaphragm pump system includes a pump housing with a drive gas chamber, a fluid chamber separated by a diaphragm, gas pressure means for providing a drive gas pressure in response to a control signal, and gas under-pressure means connected to a gas outlet port for providing a gas outlet under-pressure or sucking of gas in response to a control signal. The pump system has a displacement sensor and control circuitry connected to the displacement sensor for determining the displacement or position of the diaphragm and adapted or supplying the control signals to the gas pressure means and the gas under-pressure means.

Linear peristaltic pumps for use with fluidic cartridges. An apparatus includes a reagent cartridge configured to be received within a cartridge receptacle of a system. The reagent cartridge includes a reagent reservoir and a body including a surface that forms depressions. Each depression has a fluid inlet and a fluid outlet and is fluidly coupled to at least one other depression. The reagent cartridge also includes a deformable material coupled to the surface of the body and includes portions. Each portion covers one of the depressions to define chambers. The portions of the deformable material are movable relative to the depressions between a first position outside of a dimensional envelope of the body and a second position within the dimensional envelope of the body.

Hemodialysis and similar dialysis systems including a variety of systems and methods that make hemodialysis more efficient, easier, and/or more affordable, and include new fluid circuits for fluid flow in hemodialysis systems and a reciprocating diaphragm pump for pumping fluids. The reciprocating diaphragm pump includes a flexible diaphragm, a first rigid body having a curved pumping chamber wall, a second rigid body having an opposing curved control chamber wall. The diaphragm is interposed between the pumping chamber wall and the control chamber wall to define a pumping chamber and a control chamber. The diaphragm of the pump has a peripheral bead arranged to locate the diaphragm between the first rigid body and the second rigid body and a diaphragm body having a curved, semi-spheroid or domed shape. The diaphragm is pre-formed or molded so that during a delivery stroke of the pump, the elastic force of the diaphragm resisting its deployment into the pumping chamber prevents a peripheral portion of the diaphragm body from fully contacting the pumping chamber wall.

The invention relates to an actuating device (1) for mechanically controlling a membrane pump device (2), having a base body (4) which comprises a mounting face (7) for a membrane pump device (2) and through which a control fluid line (33, 35) passes which extends from a control fluid port (78, 79) to a control fluid opening (34, 36) which opens at the mounting face (7), a control fluid valve (74, 75) being arranged in the control fluid line (33, 35), which control fluid valve is designed to influence a cross section of the control fluid line (33, 35), and having an adjustment device (9, 14), which comprises a fluid actuator (38) arranged on the mounting face (7) for providing an adjustment movement, and a working fluid valve (81, 82) which is designed to influence a cross section of a working fluid line (85, 86) which passes through the base body (4), and the control fluid valve (74, 75) and the working fluid valve (81, 82) being electrically connected to a control device (70) which is designed to electrically control the control fluid valve (74, 75) and the working fluid valve (81, 82). Moreover, the invention relates to a membrane pump which has such an actuating device and such a membrane pump device, as well as to a blood treatment device which has such a membrane pump.