The present invention relates to a composition for improving skin whitening or thermal aging comprising 8-methoxybutin or an acceptable salt thereof as an active ingredient. The composition has no cytotoxicity, increases the expression of heat shock protein 70 (HSP70)—to prevent thermal aging, and inhibits the melanogenesis by decreasing level of tyrosinase gene expression involved in skin pigmentation. Therefore, the composition including 8-methoxybutin or an acceptable salt thereof as an active ingredient can be effectively used as a cosmetic composition, dermatologic agent, health functional food, and the like for improving skin whitening or thermal aging.

Plant-based inhibitors of MMP-9 that also function as PPAR-γ agonists, and the use of such plant-based inhibitors/agonists in modulating metabolic disorders is disclosed. The plant-based inhibitor/agonist is at least an extract obtained from the genus Anacardium.

Plant-based inhibitors of MMP-9 that also function as PPAR-γ agonists, and the use of such plant-based inhibitors/agonists in modulating metabolic disorders is disclosed. The plant-based inhibitor/agonist is at least an extract obtained from the genus Anacardium.

The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.

The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.

The present invention provides compositions and methods for improving the quality of life for a subject, particularly a child, diagnosed with autism spectrum disorder (ASD). In preferred embodiments, a supplement composition comprising natural or naturally-derived ingredients is delivered to a subject in the form of a chocolate bar or other candy alongside administration of an antiviral medication. Advantageously, the composition and methods can improve the immune health of the subject, along with other signs and symptoms associated with ASD, infections and other immunocompromising conditions.

The present invention provides compositions and methods for improving the quality of life for a subject, particularly a child, diagnosed with autism spectrum disorder (ASD). In preferred embodiments, a supplement composition comprising natural or naturally-derived ingredients is delivered to a subject in the form of a chocolate bar or other candy alongside administration of an antiviral medication. Advantageously, the composition and methods can improve the immune health of the subject, along with other signs and symptoms associated with ASD, infections and other immunocompromising conditions.

A method of reversibly increasing intestinal epithelium permeability is provided. A plant polyphenol composition, such as a pelargonidin-containing composition is enterically-administered, e.g., with a high molecular weight therapeutic agent, such as insulin, such that therapeutic agents having high molecular weights can be delivered enterically. An oral dosage form for enteric delivery of high molecular weight therapeutic agents also is provided.

Hormesis model (i.e. a toxicant excitation effect or a low dose promoting effect) is firstly used to study the relationship between the amount and efficacy of tea seed meal in feed industry. The amount of the tea seed meal as feed additive for the low dose promoting effect is determined to be 0.25-4 kg per ton of complete feed in the monogastric animal feed. The use method and the amount of the tea seed meal as feed additive can improve animal growth performance, such as increase daily weight gain, improve feed conversion ratio and decrease mortality.

Hormesis model (i.e. a toxicant excitation effect or a low dose promoting effect) is firstly used to study the relationship between the amount and efficacy of tea seed meal in feed industry. The amount of the tea seed meal as feed additive for the low dose promoting effect is determined to be 0.25-4 kg per ton of complete feed in the monogastric animal feed. The use method and the amount of the tea seed meal as feed additive can improve animal growth performance, such as increase daily weight gain, improve feed conversion ratio and decrease mortality.