Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels.

The present invention relates to a method of (and system for) characterizing the permeation of a permeant of interest between a first liquid or semi-solid and a second liquid across an interface (eg through a membrane) by using UV imaging.

Disclosed herein is an insert device for semi-dynamic leach testing, the insert device including a support and an absorptive polymer disposed on the support, the insert device characterized by a sheet-like form having a first and second major side. The device is useful in testing of both radial and unidirectional leaching of organic compounds into water from solid samples.

A method for detecting a dissolution rate of a preparation containing colloidal bismuth pectin includes steps of: according to Pharmacopoeia of the People's Republic of China, 2010 Edition, Volume 2, Appendix XC, dispersing the preparation containing the colloidal bismuth pectin into dissolution medium, and directly obtaining dissolution liquid; adding a protonic acid dissociation agent into the dissolution liquid until a hydrogen ion concentration reaches 0.8-1.2 mol/L; centrifuging for separating a supernatant; coloring the supernatant by adding a chromogen solution of citric acid or ascorbic acid and potassium iodide to obtain a test solution; calculating a dissolution amount, which is accounted by bismuth, of the colloidal bismuth pectin with a spectrophotometry method. The method of the present invention well detects dissolution curves and rates of the colloidal bismuth pectin in the preparation thereof, satisfying quality control requirements.

A method for determining whether reconstitution of a solution in a container is completed comprises the steps of: selecting a predetermined amount of a solid substance and a predetermined amount of a liquid solvent from which the reconstituted solution is to be prepared, preparing a solution by solving the predetermined amount of the solid substance in the predetermined amount of the liquid solvent, measuring the impedance (Z) or the resistance (R) of the solution, determining whether the change of the measured impedance (Z) or the resistance (R) within a measuring time interval of a predetermined duration is below a defined threshold, and determining that reconstitution of the solution is completed when the change of the measured impedance (Z) is below the defined threshold.

The present invention relates to a method of (and system for) characterising the permeation of a permeant of interest between a first liquid or semi-solid and a second liquid across an interface (eg through a membrane) by using UV imaging.

A method of estimating dissolution progress of a salt in construction of a salt cavern includes: defining, for each of a plurality of parameters, an operable range of respective parameter and an average value of the operable range of respective parameter; performing a plurality of flooding tests, by varying one particular parameter among the plurality of parameters from a lowest value to a highest value in the operable range of the one particular parameter and keeping all other parameters at the average value of respective parameter; and obtaining an analytical relationship of a mass of dissolved salt versus the one particular parameter.

The invention relates to a device for assessing the disintegration of a dosage form in the gastrointestinal tract, comprising a wall surrounding a cell for being filled with a fluid and for receiving the dosage form, further comprising a pressurizable compartment arranged exterior to the wall for repeatedly deforming the wall between a first state and a second state wherein the volume of the cell in the first state is larger than in the second state, wherein the device also comprises controlling means for quantitatively controlling a fluid flow from and into the cell, and/or for quantitatively controlling a contact force that the wall exerts on the dosage form.

Dissolution testing system which uses a dissolution vessel to conduct a test of a tablet includes a frame on which the dissolution vessel is supported, a sampling probe movable into a position at least partly in an interior of the vessel, a temperature sensor on the sampling probe for sensing temperature of the dissolution media, a camera on the sampling probe for imaging dissolution of the tablet, and heating elements outside of the vessel interior for heating the vessel wall. A cover of the vessel has a media delivery conduit and a washing conduit passing therethrough. The vessel is in a housing that rotates between a testing position in which the vessel opening is oriented upward, and at least one additional position in which the vessel opening is oriented downward to allow for fluid flow out of the vessel interior, and drying and washing of the vessel interior.

A stirring device for stirring a biphasic fluid has a stirring shaft that can be mounted with a mounting end into a stirring drive. The stirring device also has a first paddle that is arranged in a rotationally fixed manner at or near a stirring end of the stirring shaft that is opposite to the mounting end, and further has a second paddle that is arranged in a rotationally fixed manner at the stirring shaft in between the mounting end and the first paddle. The second paddle is mounted with respect to the stirring shaft in such a manner that it can be displaced in an axial direction along the stirring shaft, which allows for a change of an axial distance between the second paddle and the mounting end of the stirring shaft.