The sensor includes: a collection part 30L, 30M, 30S in which, a plurality of filter members for collecting particulate matter in exhaust gas are arranged in descending order of porosity from an exhaust upstream side to an exhaust downstream side of the exhaust gas; a pair of electrodes 32, 33 which is arranged to each of the plurality of filter members 30L, 30M, 30S and facing each other with the plurality of filter members interposed therebetween; and estimation means 42 to 44 far estimating a particulate matter amount collected on each of the plurality of filter members having different porosities based on a capacitance change amount between the pair of electrodes 32, 33.

The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.

Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.

Apparatus features a signal processor or signal processing module configured to: receive signaling containing information about a central air-core of an overflow pipe of a hydrocyclone where fluid flow is concentrated in an outer annular region of the overflow pipe that is against an inner wall of the overflow pipe during a normal operation of the hydrocyclone; and determine corresponding signaling containing information about a collapse of the central air-core of the overflow pipe of the hydrocyclone during an abnormal operation of the hydrocyclone, based upon the signaling received. The signaling contains information about a fluid flow rate of the fluid flow by detecting a change in the magnitude of a force and/or a moment on the probe.

Apparatus features a signal processor or signal processing module configured to: receive signaling containing information about a central air-core of an overflow pipe of a hydrocyclone where fluid flow is concentrated in an outer annular region of the overflow pipe that is against an inner wall of the overflow pipe during a normal operation of the hydrocyclone; and determine corresponding signaling containing information about a collapse of the central air-core of the overflow pipe of the hydrocyclone during an abnormal operation of the hydrocyclone, based upon the signaling received. The signaling contains information about a fluid flow rate of the fluid flow by detecting a change in the magnitude of a force and/or a moment on the probe.

Disclosed are devices and methods for performing biological and chemical assays, such as immunoassays and nucleic acid assays, more particularly a homogeneous assay that does not use a wash step by using the aggregation and de-aggregation processes of microparticles or nanoparticles.

Devices, systems, and methods are disclosed for improved laser speckle imaging of samples, such as vascularized tissue, for the determination of the rate of movement of light scattering particles within the sample. The system includes a structure adjoining a light source and a photo-sensitive detector. The structure can be positioned adjacent the sample (e.g., coupled to the sample) and configured to orient the light source and detector relative the sample such that surface reflections, including specular reflections and diffuse reflections, are discouraged from entering the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiply scattered photons. The system includes an operably coupled processor programmed to derive contrast metrics from the detector and to relate the contrast metrics to a rate of movement of the light scattering particles.

The present disclosure describes an apparatus and method of improving temperature uniformity and suppressing well plate warping. In an embodiment, the apparatus includes a barrier configured to be positioned above at least one well configured to contain a liquid sample, where a vessel includes the at least one well, where the vessel is transparent and is configured to be placed within a measurement chamber, where a light measurement apparatus includes the measurement chamber, where the light measurement apparatus is configured to measure light scattered from the liquid sample, where the barrier is configured to seal the at least one well from the measurement chamber, and a weighted lid configured to press a bottom surface of the vessel against a well plate retainer of the measurement chamber, thereby spreading heat among the at least one well and preventing the vessel from warping.

Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.

A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.