This invention employs solid phase extraction media and column methods to apply external and internal standards and compounds. Analytical standard or compounds including PFAS are adsorbed to a solid phase extraction media and are stored indefinitely. The standards or compounds remain stable on the solid phase extraction media without decomposing. The standards or compounds may be removed from the solid phase extraction media with an elution solvent or reagent.

The present disclosure provides an apparatus for sampling at least one analyte from a sampling fluid. The apparatus includes: a solid-phase microextraction (SPME) sampling instrument. A connector is attached to the SPME sampling instrument and is coupleable to an aerial drone. The apparatus includes a protective cover that is sized and shaped to at least partially surround the SPME sampling instrument. The SPME sampling instrument and the protective cover are movable in relation to each other between a protecting configuration and a sampling configuration. The SPME sampling instrument and the protective cover are (i) biased in the protecting configuration when the density of the fluid surrounding the SPME sampling instrument is less than the density of the sampling fluid; and (ii) biased in the sampling configuration when the density of the fluid surrounding the SPME sampling instrument is equal to or greater than the density of the sampling fluid.

The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

Embodiments in accordance with the present disclosure are directed to methods and apparatuses used for extracting heavy rare gas. An example method includes passing inlet air through an airflow path of an apparatus, removing carbon dioxide and gaseous water from the inlet air, and cooling the inlet air to a threshold temperature while passing along the airflow path. The method further includes passing the cooled inlet air through an adsorption chamber of the apparatus to adsorb heavy rare gas from the cooled inlet air while the cooled inlet air is in a gaseous state, and extracting the heavy rare gas from the adsorption chamber.

Provided are methods for isolating biomolecules, such as nucleic acids and proteins, from a sample using a silica-containing surface and/or a high salt, low pH buffer.

Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis. In particular, the sorbents includes at least one sorbent which is water-wettable and contains at least one hydrophobic component and at least one hydrophilic component and at least one of sorbent having a specific affinity for a matrix interference like phospholipids. Further disclosed is a method using the device of the present invention.

While sample extraction device including a sorbent is coupled to a sample vial containing a sample, a vacuum is drawn through the sample extraction device to evaporate the volatile matrix of the sample and carry volatilized target compounds of the sample to the sorbent. Optionally, once the volatile matrix is evaporated, the sample vial is heated and/or the vacuum level is increased to transfer heavier target compounds to the sorbent. Multiple sampling devices can be extracted in parallel. The sample extraction device can be inserted into a thermal desorption device that directly couples the sample extraction device to a gas chromatograph. In some embodiments, the sample is desorbed and analyzed using gas chromatography or another suitable technique. The techniques disclosed herein are used for analysis of volatile organic compounds and semi-volatile organic compounds in water, food, beverages, soils, and other matrices.

The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

Disclosed herein is a preprocessing apparatus that makes it possible to highly efficiently analyze specimens held by solid media, such as dried blood spots to be used for newborn mass screening or the like. The preprocessing apparatus includes: a preprocessing container setting part in which a preprocessing container containing a solid sample including a specimen to be analyzed and a solid medium holding the specimen is to be set; a carrying mechanism that carries the preprocessing container set in the preprocessing container setting part; and a preprocessing part that has a port for setting the preprocessing container carried by the carrying mechanism and that is configured to perform preprocessing including extraction processing for extracting the specimen from the solid sample contained in the preprocessing container set in the port.