An illuminator for a viewing unit of an optical inspection machine for the quality control of parts, in particular gaskets, comprises a diffusion chamber, a diffuse illumination source, a low-angle illumination source, a direct illumination source placed in the diffusion chamber, and an annular reflective element placed in the diffusion chamber. The annular reflective element is integral to the direct illumination source so that together they form a chamber closure assembly delimiting the upper end of the diffusion chamber. The chamber closure assembly can move axially by translational movement in the diffusion chamber both toward and away from the diffuse illumination source.

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

There is disclosed an apparatus for visually inspecting gemstones. The apparatus contains a first light source, a sample stage adapted to receive a gemstone thereon, and a rotating stage located below the sample stage. The rotating stage is adapted to rotate relative to the sample stage. Embodiments of the invention therefore provide a portable and automatic gemstone inspecting apparatus that provides multiple inspection methods centrally without the need to use other external devices.

Disclosed is an apparatus, such as an acoustic for parallel profiling cell-matrix adhesion at single-cell level via the introduction of localized and uniform acoustic streaming into an open chamber microfluidic device. The adherent cells within the open chamber can be detached by the streaming-induced Stokes drag force, thereby allowing an accurate determination of the relevant forces and kinetics. The current device and method includes the digital regulation of acoustic streaming from a low level to high levels, and a large number of adherent cells can be ruptured from the substrate, and the particular adhesive forces and kinetics can be determined by the applied power. The acoustic device and the associated detachment technique can characterize the adhesion dynamics and kinetics of cells, such as mammalian cells and bacterial cells. And because fibronectin mimics cells and/or cell matrices, the acoustic device and the corresponding method has broad application in determining the force(s) required to detach cells from other types of cells and/or cell matrices.

A mobile surface inspection system having a base, at least one extendable arm coupled to the base, a hollow tubular member coupled to the base, and a processor, and a method of using the same. The base has at least one front leg, at least one back leg, and at least one wheel. The extendable arm has four extension members and there is a pivotable joint connected to the fourth extension member. A light fixture is removably connected to the pivotable joint. The processor is configured to receive an image of the surface when illuminated by the light fixture, apply a high-pass filter to the image, identify surface imperfections from the filtered image. and output a position for each of the surface imperfections.

Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

A detection device, a detection apparatus, and a detection method are provided. The detection device includes a detection assembly and a driving assembly. At least two rows of detection units are provided, and the detection units are arranged in a matrix along the first direction and the second direction. During detection, the driving assembly may drive one or both of the to-be-detected object and the detection assembly to move along at least one of the first direction and the second direction, so that the detection units scan different areas of the surface of the to-be-detected object, thereby realizing a scanning of the entire surface. That is, the scanning of the surface of the to-be-detected object is completed by using multiple detection units, which improves detection efficiency for the to-be-detected surface, and realizes a relatively high imaging quality.

The prism-coupling systems and methods include using a prism-coupling system to collect a 2D digital mode spectrum of an IOX article. The mode line and critical angle positions and orientations are found by performing a weighted fit to mode line and critical angle images and are used to define a compensated mode spectrum. If mode line tilt is found, it is removed from the 2D digital mode spectrum to define the compensated mode spectrum. The compensated mode spectrum is then processed using techniques known in the art to provide a more accurate estimate of stress-related characteristics of the IOX sample versus using the uncompensated mode spectrum. Derivative-based methods of accurately establishing positions of intensity transitions in a mode spectrum of an IOX sample using a derivative spectrum and curve fitting are also disclosed.