A tape for collecting tissue samples in a manner compatible with imaging in a transmission electron microscopy (TEM) system, includes a tape substrate having two side walls forming a trough. The trough is defined by a bottom surface of the tape substrate and internal surfaces of the side walls, with an open side therebetween. A support film is attached to a top surface of the tape substrate, and a plurality of apertures is spaced at predetermined locations along the length of the tape substrate, each aperture being covered by the support film. The tape includes a stacked configuration in which the tape substrate is wound in layers, the bottom surfaces of the side walls in one layer being in contact with the support film in an immediately adjacent layer. The apertures in the second layer are aligned within the trough of the first layer, between the side walls.

An apparatus including a first and a second imaging module; a storage module; an automated transport module operable to transport at least one slide; and a controller operable to direct transport of the at least one slide by the transport module into the first imaging module and into the second imaging module. A method and a machine-readable medium including program instructions to cause a controller to perform a method including transporting at least one slide to a first imaging module using an automated transport module; capturing by the first imaging module of an image of a specimen on the at least one slide; transporting the at least one slide to a storage module using the automated transport module; and transporting the at least one slide to a second imaging module in response to a request for capturing an image in addition to the image captured by the first imaging module.

An apparatus including a first and a second imaging module; a storage module; an automated transport module operable to transport at least one slide; and a controller operable to direct transport of the at least one slide by the transport module into the first imaging module and into the second imaging module. A method and a machine-readable medium including program instructions to cause a controller to perform a method including transporting at least one slide to a first imaging module using an automated transport module; capturing by the first imaging module of an image of a specimen on the at least one slide; transporting the at least one slide to a storage module using the automated transport module; and transporting the at least one slide to a second imaging module in response to a request for capturing an image in addition to the image captured by the first imaging module.

An apparatus includes: an accommodation unit capable of accommodating a cell and liquid; and a rotation unit that produces a flow in the liquid in the accommodation unit to rotate the cell. The apparatus further includes a rotation controller unit that detects a rotation amount input from an input device, and controls the flow of the liquid produced by each of the output ports on a basis of the input rotation amount to control a rotation amount of the cell.

An apparatus includes: an accommodation unit capable of accommodating a cell and liquid; and a rotation unit that produces a flow in the liquid in the accommodation unit to rotate the cell. The apparatus further includes a rotation controller unit that detects a rotation amount input from an input device, and controls the flow of the liquid produced by each of the output ports on a basis of the input rotation amount to control a rotation amount of the cell.

The present invention relates to the methods, devices, and systems that make bio/chemical sensing (including, not limited to, immunoassay, nucleic assay, electrolyte analysis, etc.) faster, more sensitive, less steps, easy to perform, smaller amount of samples required, less or reduced (or no) needs for professional assistance, and/or lower cost, than many current sensing methods and devices. The present invention also allow a test performed by a smartphone.

A lightsheet microscope includes a detection objective for imaging a target region of a sample located in a focal plane, and an illumination objective for focusing an illumination light beam. The illumination objective and the detection objective define a sample chamber, in which a sample holder having a carrier surface is arranged. A light deflection device has a deflection surface arranged laterally offset in relation to the optical axis of the detection objective in the sample chamber which deflects the illumination light beam through the illumination objective in a direction perpendicular to the optical axis such that the deflected illumination light beam forms a lightsheet-type illumination light distribution. The light deflection device has a collision section facing toward the carrier surface. The carrier surface is inclined relative to the focal plane at a predetermined angle such that a part of the carrier surface is arranged in the focal plane.

A lightsheet microscope includes a detection objective for imaging a target region of a sample located in a focal plane, and an illumination objective for focusing an illumination light beam. The illumination objective and the detection objective define a sample chamber, in which a sample holder having a carrier surface is arranged. A light deflection device has a deflection surface arranged laterally offset in relation to the optical axis of the detection objective in the sample chamber which deflects the illumination light beam through the illumination objective in a direction perpendicular to the optical axis such that the deflected illumination light beam forms a lightsheet-type illumination light distribution. The light deflection device has a collision section facing toward the carrier surface. The carrier surface is inclined relative to the focal plane at a predetermined angle such that a part of the carrier surface is arranged in the focal plane.

The present invention relates to a cell monitoring system for automatic cell monitoring and to a compact fluorescence microscope for high resolution live-cell imaging. The microscope comprises light sources (12), light source lenses (11), excitation filters (10), and beam combining means (9). The detector unit comprises emission filter (4), tube lens (5), and a detector (7) and optionally beam folding elements (6) for compactness. A dielectric mirror (3) combines and divides the excitation and the emission light.

A sample holder for use in an optical microscope is disclosed. The sample holder includes a plasmonic layer defining a periodic array of sub-micron structures wherein the periodic array of sub-micron structures comprise an array of separated plasmonic regions. The regions may be a circle, a torus, an ellipse, a cross, rectangle, square, line, strip. Methods of performing reflection and fluorescence microscopy using such a sample holder and other sample holders are also disclosed.