Disclosed is a method of isolating extracellular vesicles and identifying membrane proteins therefrom. The method includes providing human plasma and/or serum; separating lipoproteins and extracellular vesicles from the human plasma and/or serum by a density gradient preparation, collecting the extracellular vesicles from the separated lipoproteins and extracellular vesicles; isolating and purifying the collected extracellular vesicles by using size exclusion chromatography; treating the isolated and purified extracellular vesicles with an aqueous solution to obtain membranes of the extracellular vesicles, wherein the aqueous solution has a pH in a range of 9 to 14; adding salt in a concentration range between 0.5-2.0M to the aqueous solution; isolating the membranes from the treated extracellular vesicles and identifying proteins on the isolated membranes by employing mass spectrometry.

Disclosed is a method of isolating extracellular vesicles and identifying membrane proteins therefrom. The method includes providing human plasma and/or serum; separating lipoproteins and extracellular vesicles from the human plasma and/or serum by a density gradient preparation, collecting the extracellular vesicles from the separated lipoproteins and extracellular vesicles; isolating and purifying the collected extracellular vesicles by using size exclusion chromatography; treating the isolated and purified extracellular vesicles with an aqueous solution to obtain membranes of the extracellular vesicles, wherein the aqueous solution has a pH in a range of 9 to 14; adding salt in a concentration range between 0.5-2.0M to the aqueous solution; isolating the membranes from the treated extracellular vesicles and identifying proteins on the isolated membranes by employing mass spectrometry.

The present invention will provide a novel technique to evaluate the reliability of the signal indicating the presence of secondary contributor nucleic acids in the analytical data of nucleic acid mix samples containing a small ratio of secondary contributor nucleic acids, such as cffDNA, ctDNA, and ddcfDNA.

Regression analysis is performed on the composite variables and fidelity obtained from linear combination of a numerical group that includes at least the secondary contributor component signal intensity and the secondary contributor component mix rate in the analysis data, and a model function for calculating the fidelity is obtained.

The present invention will provide a novel technique to evaluate the reliability of the signal indicating the presence of secondary contributor nucleic acids in the analytical data of nucleic acid mix samples containing a small ratio of secondary contributor nucleic acids, such as cffDNA, ctDNA, and ddcfDNA.

Regression analysis is performed on the composite variables and fidelity obtained from linear combination of a numerical group that includes at least the secondary contributor component signal intensity and the secondary contributor component mix rate in the analysis data, and a model function for calculating the fidelity is obtained.

This electrophoresis system includes an electrophoresis apparatus, an analysis apparatus, and a display unit. The analysis apparatus is configured to switch between a detailed display state in which a plurality of analysis result check displays including at least the gel image display are displayed in a result display area of the display unit and an enlarged display state in which only the gel image display among the plurality of analysis result check displays is enlarged and displayed in the result display area of the display unit.

This electrophoresis system includes an electrophoresis apparatus, an analysis apparatus, and a display unit. The analysis apparatus is configured to switch between a detailed display state in which a plurality of analysis result check displays including at least the gel image display are displayed in a result display area of the display unit and an enlarged display state in which only the gel image display among the plurality of analysis result check displays is enlarged and displayed in the result display area of the display unit.

We disclose a system. The system comprises a memory and a runtime logic. The memory stores a plurality of specialist signal profilers. Each specialist signal profiler in the plurality of specialist signal profilers is trained to maximize signal-to-noise ratio of sequenced signals in a particular signal profile detected for analytes in a particular analyte class and characterized in a particular training data set. The runtime logic, having access to the memory, is configured to execute a base calling operation by applying respective specialist signal profilers in the plurality of specialist signal profilers to sequenced signals in respective signal profiles detected for analytes in respective analyte classes during the base calling operation.

We disclose a system. The system comprises a memory and a runtime logic. The memory stores a plurality of specialist signal profilers. Each specialist signal profiler in the plurality of specialist signal profilers is trained to maximize signal-to-noise ratio of sequenced signals in a particular signal profile detected for analytes in a particular analyte class and characterized in a particular training data set. The runtime logic, having access to the memory, is configured to execute a base calling operation by applying respective specialist signal profilers in the plurality of specialist signal profilers to sequenced signals in respective signal profiles detected for analytes in respective analyte classes during the base calling operation.

Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities is provided to improve glycemic control and health management.

Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities is provided to improve glycemic control and health management.