A solid target irradiator system (10, 210) includes a target carrier feeding assembly (20, 220) coupled to a base (11, 211) for sequentially feeding individual target carriers (50, 250) from a stack of target carriers contained in a target magazine (21, 221), a target loader assembly (60, 260) coupled to the base for selectively holding each target carrier in the target magazine for subsequent advancement and retraction of a held target carrier through the solid target irradiator system, a selectively moveable dissolution assembly (100, 300) coupled to the base and selectively engageable with the target loader assembly for dissolution of target material thereon; and an airlock assembly (80, 280) coupled to the base to prepare the target carrier for subsequent irradiation.

A solid target irradiator system (10, 210) includes a target carrier feeding assembly (20, 220) coupled to a base (11, 211) for sequentially feeding individual target carriers (50, 250) from a stack of target carriers contained in a target magazine (21, 221), a target loader assembly (60, 260) coupled to the base for selectively holding each target carrier in the target magazine for subsequent advancement and retraction of a held target carrier through the solid target irradiator system, a selectively moveable dissolution assembly (100, 300) coupled to the base and selectively engageable with the target loader assembly for dissolution of target material thereon; and an airlock assembly (80, 280) coupled to the base to prepare the target carrier for subsequent irradiation.

The systems with a combination of a) methods to orient and/or stabilize the radioactive material to a magnetic axis and b) a delivery or reflection method of particles at a specific angle relative to the induced orientation to improve the penetration of said particles past the electrons shell into the nucleus for nuclear decay at a rate faster than the standard half-life calculations or similar reflection methods and systems to redirect decay-expulsion particles back at the preferred angles that increase the target material decay rate. Includes methods of pre-preparation of material, and in production use to extend useful periods of materials such that disposal of used materials deeper in their life when it is already less radioactive.

The systems with a combination of a) methods to orient and/or stabilize the radioactive material to a magnetic axis and b) a delivery or reflection method of particles at a specific angle relative to the induced orientation to improve the penetration of said particles past the electrons shell into the nucleus for nuclear decay at a rate faster than the standard half-life calculations or similar reflection methods and systems to redirect decay-expulsion particles back at the preferred angles that increase the target material decay rate. Includes methods of pre-preparation of material, and in production use to extend useful periods of materials such that disposal of used materials deeper in their life when it is already less radioactive.

Target assembly for an isotope production system. The target assembly includes a target body having a production chamber and a beam cavity that is adjacent to the production chamber. The production chamber is configured to hold a target material. The beam cavity is configured to receive a particle beam that is incident on the production chamber. The target assembly also includes a target foil positioned to separate the beam cavity and the production chamber. The target foil has a side that is exposed to the production chamber such that the target foil is in contact with the target material during isotope production. The target foil includes a material layer having a nickel-based superalloy composition.

An apparatus for producing Pb-212. The apparatus comprises an emanation box that comprises an emanation source comprising a porous non-reactive material. The emanation box receives at least one of Th-228 and Ra-224, wherein the at least one of Th-228 and Ra-224 decays to Rn-220 within the emanation box. The apparatus further includes a carrier gas feed coupled to the emanation box. The carrier gas feed directs an inert gas into the emanation box and the inert gas carries the Rn-220 out of the emanation box through a carrier gas exit port of the emanation box. The apparatus also includes one or more Rn-220 targets coupled to the carrier gas exit port. The carrier gas carries the Rn-220 from the emanation box to the one or more Rn-220 targets and the Rn-220 decays into Pb-212 within the one or more Rn-220 targets. The Pb-212 is directed into the Pb-212 collection container.

An apparatus for producing Pb-212. The apparatus comprises an emanation box that comprises an emanation source comprising a porous non-reactive material. The emanation box receives at least one of Th-228 and Ra-224, wherein the at least one of Th-228 and Ra-224 decays to Rn-220 within the emanation box. The apparatus further includes a carrier gas feed coupled to the emanation box. The carrier gas feed directs an inert gas into the emanation box and the inert gas carries the Rn-220 out of the emanation box through a carrier gas exit port of the emanation box. The apparatus also includes one or more Rn-220 targets coupled to the carrier gas exit port. The carrier gas carries the Rn-220 from the emanation box to the one or more Rn-220 targets and the Rn-220 decays into Pb-212 within the one or more Rn-220 targets. The Pb-212 is directed into the Pb-212 collection container.

The problem to be solved by the present invention is to provide a technique that allows producing a novel radiolabeled compound. The invention is a method for producing a radiolabeled compound, the method including the steps of: irradiating an alloy of a target substance with a radiation beam, to generate two or more radioisotopes from the alloy, and allowing the two or more radioisotopes to migrate into a gas; a step of generating an intermediate label by allowing a first radioisotope, from among the two or more radioisotopes having migrated into the gas, to react with a label precursor; and a step of generating a final label by allowing a second radioisotope different from the first radioisotope, from among the two or more radioisotopes having migrated into the gas, to react with the intermediate label.

The problem to be solved by the present invention is to provide a technique that allows producing a novel radiolabeled compound. The invention is a method for producing a radiolabeled compound, the method including the steps of: irradiating an alloy of a target substance with a radiation beam, to generate two or more radioisotopes from the alloy, and allowing the two or more radioisotopes to migrate into a gas; a step of generating an intermediate label by allowing a first radioisotope, from among the two or more radioisotopes having migrated into the gas, to react with a label precursor; and a step of generating a final label by allowing a second radioisotope different from the first radioisotope, from among the two or more radioisotopes having migrated into the gas, to react with the intermediate label.

A method of generating a radionuclide includes receiving a container in a container receptacle of a radionuclide generator, and moving the container in the container receptacle from a first pose to a second pose. The method also includes exposing an interior surface of the container to a precursor radionuclide source while the container is in the second pose, and allowing sufficient time for the precursor radionuclide source to decay into one or more progeny radionuclides and to emanate the one or more progeny radionuclides into the container. The method further includes isolating the precursor radionuclide source from the container while the container is in the first pose.