A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.

Disclosed is a calibrator device designed to measure the activity of a radio element, including: an ionization chamber, intended to receive the radio element; and electronic/computer system for controlling the operation of the calibrator device. The electronic/computer system includes voice control, which include: at least one microphone capable of capturing a voice instruction emitted by the operator; a recognition module designed to convert the voice instruction into a request that can be executed by the electronic/computer system; and a control module designed to control the execution of the request by the electronic/computer system.

A nuclear medicine infusion system may be used to generate and infuse radioactive liquid into a patient undergoing a diagnostic imaging procedure. In some examples, the infusion system includes a frame that carries a radioisotope generator that generates radioactive eluate via elution. The frame may also carry a beta detector and a gamma detector. The beta detector can be positioned to measure beta emissions emitted from the radioactive eluate supplied by the generator. The gamma detector can be positioned to measure gamma emissions emitted from a portion of the radioactive eluate to evaluate a safety of the radioactive eluate delivered by the infusion system.

A nuclear medicine infusion system may be used to generate and infuse radioactive liquid into a patient undergoing a diagnostic imaging procedure. In some examples, the infusion system includes a frame that carries a radioisotope generator that generates radioactive eluate via elution. The frame may also carry a beta detector and a gamma detector. The beta detector can be positioned to measure beta emissions emitted from the radioactive eluate supplied by the generator. The gamma detector can be positioned to measure gamma emissions emitted from a portion of the radioactive eluate to evaluate a safety of the radioactive eluate delivered by the infusion system.

A terminally sterilized isotope generator for producing an alpha-emitting Lead-212 (.sup.212Pb) daughter isotope by emanation of Radon-220 (.sup.220Rn) gas from Radium-224, comprising a closed retainer assembly including a parent-isotope chamber for receiving a parent isotope, a daughter-isotope chamber for collecting the .sup.212Pb daughter isotope, and a gas permeable membrane separating the parent-isotope chamber from the daughter-isotope chamber, wherein the parent isotope is naturally decaying into .sup.220Rn within the parent-isotope chamber, wherein the gas permeable membrane allows the .sup.220Rn to passively pass therethrough, wherein the .sup.220Rn is spontaneously decaying into .sup.212Pb within the daughter-isotope chamber. An eluent is delivered in the daughter-isotope chamber, to elute in a liquid form the .sup.212Pb generated in a gaseous form; and a collection container collects the .sup.212Pb daughter-isotope eluted. The isotope generator is scalable based on required .sup.212Pb daughter-isotope quantities to be generated, the .sup.212Pb daughter-isotope quantities ranging from 1 mCi to 500 mCi.

A terminally sterilized isotope generator for producing an alpha-emitting Lead-212 (.sup.212Pb) daughter isotope by emanation of Radon-220 (.sup.220Rn) gas from Radium-224, comprising a closed retainer assembly including a parent-isotope chamber for receiving a parent isotope, a daughter-isotope chamber for collecting the .sup.212Pb daughter isotope, and a gas permeable membrane separating the parent-isotope chamber from the daughter-isotope chamber, wherein the parent isotope is naturally decaying into .sup.220Rn within the parent-isotope chamber, wherein the gas permeable membrane allows the .sup.220Rn to passively pass therethrough, wherein the .sup.220Rn is spontaneously decaying into .sup.212Pb within the daughter-isotope chamber. An eluent is delivered in the daughter-isotope chamber, to elute in a liquid form the .sup.212Pb generated in a gaseous form; and a collection container collects the .sup.212Pb daughter-isotope eluted. The isotope generator is scalable based on required .sup.212Pb daughter-isotope quantities to be generated, the .sup.212Pb daughter-isotope quantities ranging from 1 mCi to 500 mCi.

Methods, kits, and compositions are described for the detection and treatment of premalignant lesions. This early detection allows patients to avoid the risks associated with repetitive imaging often employed to seek differentiation between developing cancer and inflammation. The method comprises (a) administering to the subject a radiographic tracer for a sodium/glucose cotransporter (SGLT): (b) performing a radiographic detection scan of the subject; and (c) detecting signal emitted by the tracer taken up in the scanned subject, whereby detected signal in the subject is indicative of a pre-malignant lesion. In some embodiments, the method further comprises administering an inhibitor of sodium-glucose transporter 2 (SGLT2), such as gliflozin, to a subject in whom a pre-malignant lesion has been detected. In some embodiments, the pre-malignant lesion is in tissue that expresses SGLT2, such as a lung, prostate, bladder, breast, or pancreatic lesion.

A method of assisting with authenticating a workpiece is provided. In another aspect, ions are generated, accelerated in an accelerator, an isotope is created, and then the isotope is implanted within a workpiece to assist with authenticating of the workpiece. A further aspect includes a workpiece substrate, a visual marker and an isotope internally located within the substrate adjacent the visual marker.

A method of assisting with authenticating a workpiece is provided. In another aspect, ions are generated, accelerated in an accelerator, an isotope is created, and then the isotope is implanted within a workpiece to assist with authenticating of the workpiece. A further aspect includes a workpiece substrate, a visual marker and an isotope internally located within the substrate adjacent the visual marker.

Radiation shielding structures comprising bulk-solidifying amorphous alloys and methods of making radiation shielding structures and components in near-to-net shaped forms are provided.