Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.

Apparatus and methods are disclosed for vibration-free cryogenic cooling, suitable for TEM and other analytic equipment. A thermal battery includes one or more of: a cryocooler, a thermal switch, a thermal cold storage reservoir, and a cold finger. The thermal reservoir is mounted outside a sample chamber. The cold finger provides thermal coupling between the reservoir and a sample holder inside the sample chamber. In varying embodiments, sample holder and sample temperatures are regulated by a heater or by an inline variable thermal resistor. Cyclic phased operation includes cooling the reservoir, decoupling the cryocooler from the reservoir, and temperature-regulated passive vibration-free thermal energy extraction from sample to reservoir. The described system delivers a stand time of 12 hours at 20 K. Temperature regulation, a hybrid thermal switch, damping of thermal fluctuations, and material selection are described.

Apparatus and methods are disclosed for vibration-free cryogenic cooling, suitable for TEM and other analytic equipment. A thermal battery includes one or more of: a cryocooler, a thermal switch, a thermal cold storage reservoir, and a cold finger. The thermal reservoir is mounted outside a sample chamber. The cold finger provides thermal coupling between the reservoir and a sample holder inside the sample chamber. In varying embodiments, sample holder and sample temperatures are regulated by a heater or by an inline variable thermal resistor. Cyclic phased operation includes cooling the reservoir, decoupling the cryocooler from the reservoir, and temperature-regulated passive vibration-free thermal energy extraction from sample to reservoir. The described system delivers a stand time of 12 hours at 20 K. Temperature regulation, a hybrid thermal switch, damping of thermal fluctuations, and material selection are described.

This disclosure pertains to methods and apparatus for drying bio-specimens.

This disclosure pertains to methods and apparatus for drying bio-specimens.

The present invention relates to a system for analysing volatile organic compounds (VOCs) in soil comprising an apparatus and a soil VOC sensor strip, wherein the apparatus comprises a sampling chamber for receiving soil, a sensor strip aperture in the sampling chamber for positioning the sensor strip in fluid communication with the sampling chamber, a power source and an electrical resistance detector, wherein the sensor strip comprises a flexible substrate with a first surface and an array of semiconductor polymer sensors arranged on the first surface, wherein each of the semiconductor polymer sensors comprises a pair of electrodes, wherein the pair of electrodes comprises a first electrode and a second electrode, wherein a semiconductor polymer is disposed between the first electrode and the second electrode, and wherein the sensor strip is electrically connectable to the power source and the electrical resistance detector.

The present invention relates to a system for analysing volatile organic compounds (VOCs) in soil comprising an apparatus and a soil VOC sensor strip, wherein the apparatus comprises a sampling chamber for receiving soil, a sensor strip aperture in the sampling chamber for positioning the sensor strip in fluid communication with the sampling chamber, a power source and an electrical resistance detector, wherein the sensor strip comprises a flexible substrate with a first surface and an array of semiconductor polymer sensors arranged on the first surface, wherein each of the semiconductor polymer sensors comprises a pair of electrodes, wherein the pair of electrodes comprises a first electrode and a second electrode, wherein a semiconductor polymer is disposed between the first electrode and the second electrode, and wherein the sensor strip is electrically connectable to the power source and the electrical resistance detector.

Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.

Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.

A vaporizer device and associated methodology for providing accurate sampling through substantially efficient, complete and uniform single pass vaporization of a liquid sample by avoiding liquid pre-vaporization and downtime attributable to system damage from incomplete vaporization, particularly in the distribution, transportation, and custody transfer of natural gas. The vaporizer device includes at least one input port for receiving a liquid sample, a channel for directing the liquid to a vaporizer core and a heating assembly within the vaporizer core configured to flash vaporize the liquid sample. The vaporized sample can then be passed to an outlet for sample analysis.