G01N2015/0687

System and method for detecting pathogens in an environment via an electrostatic air sampler

One variation of a pathogen detection system includes an air sampler and a cartridge. The air sampler includes: a housing defining an inlet and an outlet; a tunnel arranged within the housing and extending between the inlet and the outlet; a charge electrode arranged within the tunnel proximal the inlet; a cartridge receptacle arranged proximal the outlet and comprising a cartridge terminal; and a power supply configured to drive a voltage between the charge electrode and the cartridge terminal. The cartridge includes: a substrate; a collector plate arranged on the substrate and configured to collect charged bioaerosols moving through the tunnel; and a connector configured to transiently engage the cartridge receptacle to locate the substrate and the collector plate within the tunnel and electrically couple the collector plate to the cartridge terminal.

SMART NEBULIZER

A nebulizer system capable of identifying when activation has occurred and aerosol is being produced. The nebulizer system monitors the inhalation and exhalation flow generated by the patient and communicates proper breathing technique for optimal drug delivery. The nebulizer system may monitor air supply to the nebulizer to ensure it is within the working range and is producing, or is capable of producing, acceptable particle size and drug output rate. When a patient, caregiver or other user deposits or inserts medication into the nebulizer, the nebulizer system is able to identify the medication and determine the appropriate delivery methods required to properly administer the medication as well as output this information into a treatment log to ensure the patient is taking the proper medications. The system is able to measure the concentration of the medication and volume of the medication placed within the medication receptacle, e.g., bowl.

SYSTEMS AND METHODS FOR IDENTIFYING PROTEIN AGGREGATES IN BIOTHERAPEUTICS
20220326129 · 2022-10-13 · ·

Systems and methods for inspecting particles in a liquid beneficial agent are provided. Inspecting particles in a liquid beneficial agent includes selectively illuminating at least a portion of a liquid beneficial agent contained within a container using an excitation beam configured to excite photoluminescent particles in the liquid beneficial agent to emit an emission light and produce scattered excitation light, filtering the illuminated portion of the liquid beneficial agent to transmit the emission light and block the scattered excitation light, obtaining an image of the filtered emission light, analyzing image data representing the image of the filtered emission light to detect regions of the image representing the intrinsic photoluminescence of the photoluminescent particles, measuring an intensity of the regions of the image representing the intrinsic photoluminescence of the photoluminescent particles, and determining a size or number of the photoluminescent particles from the measured intensity of the regions.

FINE-PARTICLE SAMPLING DEVICE AND METHOD OF SAMPLING FINE PARTICLES
20220326135 · 2022-10-13 ·

A fine-particle sampling device for sampling fine particles in a liquid includes a tubular first electrode whose both ends in an axial direction thereof are open; a second electrode extending in the axial direction of the first electrode and disposed in the inside of the first electrode to be spaced from an inner surface of the first electrode; a supplier that supplies a liquid to the inside of the first electrode and causes the liquid to be stored at a portion of the inner surface in a direction around an axis B of the first electrode; a voltage applicator that applies a voltage between the first electrode and the second electrode; a driver that rotates the first electrode around a rotational axis extending in the axial direction of the first electrode and passing through the inside of the first electrode; and a retriever that retrieves the stored liquid.

System and method for detecting airborne pathogens
11662278 · 2023-05-30 · ·

An air sampling system is disclosed. The air sampling system includes: an air inflow channel having an air inlet portion at a top end, the air inflow channel being oriented substantially vertically; a fan configured to cause air in a sampling environment to flow into the air inflow channel via the inlet portion; a cooling unit for cooling air in the air inflow channel, the cooling unit disposed downstream of the inlet portion; a collection chamber for collecting liquid water condensed from air in the air inflow channel, the collection chamber being fluidly connected to the air inflow channel; and a sensing unit for determining a volume of liquid in the collection chamber, wherein the cooling unit is controlled in response to signals generated by the sensing unit.

Sample inspection apparatus

According to one embodiment, a sample inspection apparatus includes a photodetection circuitry, an image sensor, processing circuitry, and an output interface. The photodetection circuitry has light incident on an optical waveguide in an inspection container and detects the light having propagated within the optical waveguide and coming out of the optical waveguide. The image sensor acquires an image signal for the optical waveguide, using scattered light originated from the light propagating within the optical waveguide. The processing circuitry acquires one or more inspection index values based on at least one of an output of the photodetection circuitry or an output of the image sensor. The output interface outputs a result of processing by the processing circuitry.

FLOW CYTOMETRY EVALUATION OF BIOLOGICAL MATERIAL FOR UNASSOCIATED VIRUS-SIZE PARTICLES

A method for evaluating a biological material for unassociated virus-size particles having a particular epitope uses a fluorescent antibody stain specific for binding with the epitope and a fluid sample with the virus-size particles and fluorescent antibody stain is subjected to flow cytometry with identification of fluorescent emission detection events indicative of passage through a flow cell of a flow cytometer of unassociated labeled particles of virus size including such a virus-size particle and fluorescent antibody stain.

DIAGNOSTIC CHIP

A microfluidic diagnostic chip may comprise a microfluidic channel, a functionalizable enzymatic sensor in the microfluidic channel, the functionalizable enzymatic sensor comprising a binding surface to bind with a biomarker in a fluid, and a microfluidic pump to pass the fluid over the binding surface. A microfluidic device may comprise a number of pumps to pump a fluid though the number of microfluidic channels and a number of microfluidic channels comprising at least one sensor to detect a change in a chemical characteristic of the fluid in response to presence of the fluid on the sensor

Cleaning of a 3D Printed Article
20170363377 · 2017-12-21 ·

The present disclosure relates to a method and apparatus for cleaning a 3D printed article, in particular a 3D printed heat exchanger. After 3D printing, an article may have internal passages formed from bonded powder and said passages may contain unbonded powder that needs to be removed before further use of/processing of the article. To remove this unbonded powder, the article is filled with a cleaning fluid and vibrated. The cleaning fluid is then pumped out of the article and past a sensor that generates a magnetic field. The sensor detects the presence of powder particles in the fluid by detecting a perturbation of the magnetic field caused by said particles. The fluid is then filtered and returned to a reservoir for use. The sensor may indicate the article is sufficiently clean when a detected concentration of particles in the fluid drops below a threshold.

PERMEATION ESTIMATION APPARATUS AND PERMEATION ESTIMATION METHOD
20230184660 · 2023-06-15 ·

A permeation estimation apparatus includes an interface configured to connect to a sensor that measures a concentration of a component, of a soaked material, that is eluted in a soaking solution in which the soaked material is soaking, and a controller configured to acquire the concentration of the component from the interface and estimate the degree of permeation of the soaking solution with respect to the soaked material based on the measurement result of the concentration of the component.