The present invention relates to an improved method for determining the identity of a biomolecule using interferometric light scattering apparatus, notably distinguishing between variants of biomolecules, such as viral serotypes and the like. Such a method has potential to simplify the testing for biological manufacture and for diagnosing disease, monitoring environmental issues and determination of contaminants.

There is provided a fine dust measurement module that includes a fluid inlet into which fluid including fine dust with particles of various diameters is flowed, a first channel through which, of the fine dust introduced through the fluid inlet, first fine dust with particles having a diameter greater than or equal to a first diameter passes, a second channel through which, of the fine dust introduced through the fluid inlet, second fine dust with particles having a diameter less than the first diameter passes, a flow ratio control nozzle arranged in the first channel and configured to control a flow ratio between fluid flowing into the first channel and fluid flowing into the second channel, and a fine dust sensor configured to sense fine dust flowing into the second channel.

The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.

A spectrometer device for analysis of aerosol particles, dusts, and other microparticles and/or nanoparticles includes an electrospray ionization source supplying a particle stream to an aerodynamic lens that focuses and collimates a beam of particles. An electrostatic trap accepts the beam of particles and traps a single trapped particle at a time in the electrostatic trap to oscillate with a measurable amplitude and frequency. A sensor senses the amplitude and frequency, and a processor determines a calculated mass to charge ratio from the amplitude and frequency of oscillation of the trapped particle in real time. A method creates a focused stream of micro or nanoparticles, traps a single particle at a time in an electrostatic trap. The amplitude and frequency of the oscillation of the trapped particle is sensed. The mass to charge ratio is determined from the amplitude and frequency of oscillation. Particles can be accelerated into a target.

A method for measuring a property of an object, the method comprising: dipping a solid immersion lens into a solution comprising the object, such that the object interacts with the surface of the solid immersion lens; illuminating the surface of the solid immersion lens with an illumination source and detecting the scattered light from the object using an interferometric scattering microscope; measuring a property of the object using the detected scattered light; withdrawing the solid immersion lens from the solution; and subsequently cleaning the solid immersion lens such that the object is removed from the surface of the solid immersion lens.

Methods for determining the hardness and/or ductility of a material by compression of the material are provided as a first aspect of the invention. Typically, compression is performed on multiple sides of a geologic material sample in a contemporaneous manner. Devices and systems for performing such methods also are provided. These methods, devices, and systems can be combined with additional methods, devices, and systems of the invention that provide for the analysis of compounds contained in such samples, which can indicate the presence of valuable materials, such as petroleum-associated hydrocarbons. Alternatively, these additional methods, devices, and systems can also stand independently of the methods, devices, and systems for analyzing ductility and/or hardness of materials.

The invention relates to methods and apparatus for detecting properties of heterogeneous samples, including detecting properties of particles or fluid droplets in industrial processes. Embodiments disclosed include a particle characterization method, comprising: providing a fluid containing suspended particles; causing at least a first subset of the suspended particles to flow past a first two-dimensional array detector (24); illuminating the first subset of suspended particles as they flow past the first two-dimensional array detector (24) in the fluid; acquiring a plurality of images of the first subset of particles as they flow past the first two-dimensional array detector (24) in the fluid; and automatically counting the particles in the images.

Devices and methods for detecting particulate matter are described herein. One device includes a laser, a reflector, an ellipsoidal reflector, and a detector, wherein the laser is configured to emit a beam, the reflector is configured to reflect the beam toward the ellipsoidal reflector, and the ellipsoidal reflector has a first focal region located on a path of the reflected beam, and a second focal region located at a surface of the detector.

An optomechanical device with mechanical elements and optical filters for actuating and/or detecting movement of the elements, including a support, and on the support: an array of mechanical elements anchored to the support and configured to move with respect thereto, and an actuating and/or detection device actuating the elements and/or detecting movement of the elements or frequency variations of the movement. The actuating and/or detection device includes an array of optical filters. Each filter resonates at a particular wavelength and is coupled to one of the elements. The actuating and/or detecting device is positioned in vicinity of all or some of the elements, between the elements and the support. The optical filters are fixed with respect to the support and the mechanical elements and the optical filters are superimposed.

A system for handling biological cells includes a main channel having an inlet end and an outlet end, and, at least over a first portion from the inlet end, including a cross section such that a cell circulating in the portion undergoes mechanical stresses. The system further includes first means for detecting the presence of a cell at the inlet end of the main channel and at least one access zone opening into the main channel between its inlet end and its outlet end in the first portion, in order to make it possible to exert an action on the cell. The system also includes means for displacing the cell in order to control the displacement of the cell between the inlet end and the outlet end.