A system and method includes resonator device to detect cells or other particles through light and/or vibration sensing.

A system and method includes nano opto-mechanical-fluidic resonators (nano-resonators), e.g., for identification of particles, e.g., single viruses and/or cells.

A sample droplet generator transforms a segmented array of sample material into a continuous stream of droplets containing analytes. The droplets may serve as a sample source for a wide range of detectors and analytical instruments. As one example, the droplets may be introduced into an ion source of a spectrometer that measures ions produced from the droplets or photons emitted from the droplets.

The present invention describes a fluidic device for measuring at least one of corpuscle mass density and weight. The fluidic device comprises a sedimentation chamber fluidly connected to an inlet channel configured to be immersed in a liquid. The fluidic device further comprises a pumping system connected to the sedimentation chamber. The pumping system is adapted to control the flow of liquid in the sedimentation chamber. A processor of the fluidic device is configured to obtain corpuscle data related to a corpuscle in at least one region of the sedimentation chamber; and calculate at least one of corpuscle mass density and weight based on the data received.

The present invention relates to an analyzer and method for simultaneously determining both size and material properties of a single nanoparticle. In the present invention, both the mass of the nanoparticle and the change in capacitance induced on a capacitive sensor by the nanoparticle are measured simultaneously, and thus the size and material properties of the nanoparticle are determined. An analyzer for simultaneously determining the size and material properties of a nanoparticle is described with the present invention, this device comprises a mass sensor, a capacitor sensor and a common precise measurement region of the mass sensor and capacitor sensor, wherein said mass sensor and capacitor sensor provide common measurement. The present invention can be used in the field of biomedical, environmental engineering and materials engineering.

The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.

A method to determine a mass of particles collected on a collection membrane having a first surface and a second surface. The particles to be analysed are deposited on the first surface. In a first step, the particles of the first surface are scanned with a Raman spectrometer and a preliminary Raman signal is collected. In a second step, at least one additional physical property of the particles is determined. In a third step, a correction factor is calculated based on the additional physical property. In a fourth step, a final Raman signal is calculated based on the correction factor and the preliminary Raman signal. In a fifth step the actual mass of the particles is determined based on the final Raman signal.

The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

There is provided a particle mass measurement device including a sensing channel that generates a sensing clock signal, a reference channel that generates a reference clock signal, a counter and a controller. The sensing channel includes a first surface acoustic wave (SAW) sensor that generates a SAW, a first amplifier that amplifies the SAW, and a first bias generator that applies a first bias voltage to the first amplifier. The reference channel includes a second SAW sensor that generates a SAW, a second amplifier that amplifies the SAW generated by the second SAW sensor, a second bias generator that applies a second bias voltage to the second amplifier. The counter generates a first output signal based on the sensing clock signal, and generates a second output signal based on the reference clock signal. The controller adjusts magnitude of the first bias voltage, or adjusts magnitude of the second bias voltage.

The method uses a suspended resonating microcapillary device, and obtains simultaneously three parameters of the analytes: mass, size and refractive index, enabling the unequivocal classification of the analytes flowing in real time, based on the resonance frequency displacement and the change in reflectivity of the transparent microcapillary. The method comprises the stages of: the obtaining of a measurement of the reflectivity of the sample analytes within the capillary at each moment in time; the obtaining of a mechanical reference signal (T.sub.t) of the change in resonance frequency of the microcapillary caused by the sample analytes over time; and the detection of the passage of the particle through an area of the capillary, and the obtaining of the points of passage of the ends of the analytes through the centre of the illuminated area, obtaining an optical signal T.