A system for processing sample entities includes a chamber including a surface having an array of measurement regions, wherein at least one measurement region comprises a first set of one or more electrodes and a second set of one or more electrodes, wherein the first set of electrodes is configured to measure a first characteristic of a sample entity when the sample entity is traversing the first set of electrodes, and wherein the second set of electrodes is configured to selectively retain the sample entity in the at least one measurement region based at least in part on the measured first characteristic and/or measure a second characteristic of the sample entity.

A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.

A velocimeter/nephelometer for measuring the three-dimensional velocity and/or size and/or shape of a particle. A set of laser interferometers and a set of photodiode detectors are arranged on a two-dimensional platform. Each laser interferometer produces a laser beam, with the beams intersecting within an inner area of the platform. Two of the laser interferometers produce like-oriented fringe patterns with an angular separation between the propagation direction of their beams of ninety degrees. A third of the laser interferometers produces a beam with the fringe pattern oriented orthogonal to the fringe patterns of the other two laser interferometers. Each detector is positioned and filtered to detect light from an associated laser interferometer, the light having been scattered by a particle as the particle passes through a volume of observation.

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

A method and apparatus for sizing and imaging an analyte. The apparatus including an electromagnetic resonator, an input port, an output port, a microfluidic substrate, and a microfluidic channel having a first fluid port and a second fluid port wherein a first analyte species is manipulated and analyzed within the microfluidic channel. The electromagnetic resonator further including at least one ground plane for the electromagnetic resonator, and at least one signal path for the electromagnetic resonator.

According to the present invention there is provided a first particle sensor, a second particle sensor and a device for characterisation of one or more particles in a fluid sample comprising a first particle sensor and/or at least one second particle sensor. A method for characterising one or more particles in a fluid sample is also disclosed.

The present technique provides a simple, cost-effective and robust method for re-alignment of interfaces between cell conjugates parallel to the coverslip. The technique is based on placement of two cell types, to subsequently form an interaction between the cell types, to opposing coverslips and then bringing them together before or during imaging, for either fixed or live cell imaging. Spacer particles having defined parameters control the z-separation and the relative lateral position of the opposing coverslips. We show that our method allows most types of super-resolution imaging.

Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

In one embodiment, a method includes obtaining a borehole image deriving from a downhole tool in a wellbore of a geological formation, identifying one or more patches that correspond to sediment particles on the fullbore image, computing one or more characteristics for each of the one or more patches. The one or more characteristics may include long/short axis length, size, roundness, sphericity, orientation, or some combination thereof. The method may also include displaying a visual representation for each of the one or more characteristics.

The device (100) comprises a cavity (101) and at least two microporous membranes (102), wherein the microporous membranes (102) are arranged in series in the cavity (101) and divide the cavity (101) into a plurality of chambers (1011); each of the microporous membranes (102) is provided with micropores (103), and two adjacent chambers (1011) are in communication via the micropores (103); and each of the chambers (1011) is provided with an electrode (1012).