A method for optically detecting biomarkers in a biosensor is disclosed, wherein the optical detection obtains spatially and spectrally resolved optical signals from a sample on a biosensor, and one or more of these spatially and spectrally resolved optical signals can be analyzed in parallel with image acquisition. The image analysis comprises reading data of the acquired images, correcting them to reduce inhomogeneities and noise, localizing particles in the images, characterizing each particle individually to obtain its position and characterization parameters, and classifying the particles based on their characterization parameters. Using the number of particles per class for all the acquired images of the sample, a statistical value is calculated per sample and each statistical value is correlated with an indication of the presence of a biomarker in the sample.

Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.

A fiber-optic sensing apparatus is provided, including an outer sleeve, an optical fiber sensor arranged within the outer sleeve, and a filling medium. The optical fiber sensor is capable of detecting a change of a refractive index or a change of surface plasmon waves over an outer surface of the outer sleeve. The filling medium may have a matching refractive index with the outer sleeve and with the optical fiber sensor. The outer sleeve may be exposed directly to the outside medium, or may be coated with at least one functional film layer such as a surface plasmon resonance (SPR)-active base film layer, or a reactive film layer that is reactive to a target molecule in the outside medium.

A fiber-optic sensing apparatus is provided, including an outer sleeve, an optical fiber sensor arranged within the outer sleeve, and a filling medium. The optical fiber sensor is capable of detecting a change of a refractive index or a change of surface plasmon waves over an outer surface of the outer sleeve. The filling medium may have a matching refractive index with the outer sleeve and with the optical fiber sensor. The outer sleeve may be exposed directly to the outside medium, or may be coated with at least one functional film layer such as a surface plasmon resonance (SPR)-active base film layer, or a reactive film layer that is reactive to a target molecule in the outside medium.

Systems and methods for performing a contamination estimation of a downhole sample including at least a formation fluid and a filtrate are provided. A plurality of downhole signals are obtained from the downhole sample and one or more of the signals are conditioned. At least two of the conditioned signals or downhole signals are fused into a multivariate dataset. A principle component analysis (PCA) is performed on the fused multivariate dataset to determine optical and density properties of the formation fluid. Based on at least the PCA, optical and density properties of the filtrate are determined. From the optical and density properties of the formation fluid and of the filtrate, a multivariate calculation is performed to generate concentration profiles of the formation fluid and the filtrate.

The present invention provides a sensing device for detecting an analyte containing a non-metallic element such as F. A working sensor has a 3D array of voids each having a void internal wall. The void internal walls have cavities each having a cavity internal wall made from a material containing the non-metallic element. A binding of the analytes to the cavities induces a detectable variation of the optical property of the 3D array of voids. The invention exhibits numerous technical merits such as high sensitivity, high specificity, fast detection, ease of operation, low power consumption, zero chemical release, and low operation cost, among others.

The present invention provides a sensing device for detecting an analyte containing a non-metallic element such as F. A working sensor has a 3D array of voids each having a void internal wall. The void internal walls have cavities each having a cavity internal wall made from a material containing the non-metallic element. A binding of the analytes to the cavities induces a detectable variation of the optical property of the 3D array of voids. The invention exhibits numerous technical merits such as high sensitivity, high specificity, fast detection, ease of operation, low power consumption, zero chemical release, and low operation cost, among others.

The present disclosure relates generally to a sensor chip and methods for the detection of an analyte. In particular, the disclosure relates to a sensor chip for detecting an analyte in a subject suffering from a neurodegenerative disease. The sensor chip comprises a conductive layer on a membrane support layer, wherein a plurality of apertures extend through the conductive layer and the membrane support layer and are arranged such that illumination of the conductive layer and/or the membrane support layer produces a surface plasmon resonance.

The present disclosure relates generally to a sensor chip and methods for the detection of an analyte. In particular, the disclosure relates to a sensor chip for detecting an analyte in a subject suffering from a neurodegenerative disease. The sensor chip comprises a conductive layer on a membrane support layer, wherein a plurality of apertures extend through the conductive layer and the membrane support layer and are arranged such that illumination of the conductive layer and/or the membrane support layer produces a surface plasmon resonance.

A recording apparatus includes a channel through which liquid to be supplied to a recording head that ejects the liquid flows and a concentration measuring unit including a light emitting unit and a light receiving unit and configured to measure the concentration of the liquid, wherein the concentration measuring unit is disposed at a direction change portion at which the liquid flowing through the channel changes in direction.