A micro light-emitting diode (μLED) chip includes a first electrode layer, a second semiconductor layer located on a surface of the first electrode layer, and a first semiconductor layer located on a side of the second semiconductor layer away from the first electrode layer, and a light-emitting layer located between the first semiconductor layer and the second semiconductor layer. The second semiconductor is electrically connected to the first electrode layer, and is configured to transmit first carriers. The first semiconductor layer is configured to transmit second carriers. The light-emitting layer is configured to be excited to emit light upon combination of the first carriers and the second carriers. A surface of the first semiconductor layer away from the light-emitting layer is a concave-convex microstructure, and convex portions of the concave-convex microstructure are configured to receive an electron beam.

A micro light-emitting diode (μLED) chip includes a first electrode layer, a second semiconductor layer located on a surface of the first electrode layer, and a first semiconductor layer located on a side of the second semiconductor layer away from the first electrode layer, and a light-emitting layer located between the first semiconductor layer and the second semiconductor layer. The second semiconductor is electrically connected to the first electrode layer, and is configured to transmit first carriers. The first semiconductor layer is configured to transmit second carriers. The light-emitting layer is configured to be excited to emit light upon combination of the first carriers and the second carriers. A surface of the first semiconductor layer away from the light-emitting layer is a concave-convex microstructure, and convex portions of the concave-convex microstructure are configured to receive an electron beam.

Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting anti-repeat-associated non-ATG (RAN) protein antibodies in a subject (e.g., a subject that has been administered a therapeutic anti-RAN protein antibody or a vaccine against a disease or disorder associated with RAN protein expression, translation, and/or accumulation, for example amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD)). In some embodiments, methods described by the disclosure comprise detecting one or more anti-RAN protein antibodies in a biological sample obtained from a subject by an electrochemiluminescence-based immunoassay using one or more target di-amino acid repeat peptides. In some embodiments, the disclosure relates to kits comprising one or more di-amino acid repeat peptides and an electrochemiluminescence-based immunoassay plate and/or reagents.

Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting anti-repeat-associated non-ATG (RAN) protein antibodies in a subject (e.g., a subject that has been administered a therapeutic anti-RAN protein antibody or a vaccine against a disease or disorder associated with RAN protein expression, translation, and/or accumulation, for example amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD)). In some embodiments, methods described by the disclosure comprise detecting one or more anti-RAN protein antibodies in a biological sample obtained from a subject by an electrochemiluminescence-based immunoassay using one or more target di-amino acid repeat peptides. In some embodiments, the disclosure relates to kits comprising one or more di-amino acid repeat peptides and an electrochemiluminescence-based immunoassay plate and/or reagents.

Provided are a flow cell and an automatic analysis device which are excellent in the long-term stability of the flow path shape of the flow cell and can improve the reproducibility of analysis. The flow cell (6) of the present invention includes a base (18) including an inlet and outlet (35, 36) for a flow path of a reaction solution containing an analyte; an electrode (16A, 16B) for applying a voltage to the analyte; a light receiving window (22) made of a member that transmits light emitted from the analyte by the voltage applied on the electrode, a gasket (18A) provided between the base (18) and the light receiving window (22), and a flow chamber (17) surrounded by the base (18), the light receiving window (22) and the gasket (18A), in which the gasket (18A) has a deformation amount of 0 mm or more and 0.2 mm or less in a chemical immersion test, and the surface adhesive force of 14 N/cm.sup.2 or more and 40 N/cm.sup.2 or less in a surface adhesion evaluation

A device for monitoring a measurement object, comprising: an active unit having a light source emitting light with a wavelength spectrum and an optical detector. An optical link passes the emitted light to a at least one passive unit. Each passive unit comprises a sensor and a selector for diverting the emitted light to the sensor. The sensor comprises a luminescent material being directly or indirectly affected by the emitted light diverted by the selector. The sensor is sensitive to an external influence by the measurement object for producing a modulated signal, which is passed to said detector via the optical link. The luminescent material may be a fluorescent material, which is directly irradiated by the emitted light from the light source.

Biological research requires isolation and analysis of material, for example, RNA, DNA and protein, from tissue samples. The methods and compositions described herein allow for high resolution imaging of large and intact tissue samples, and subsequent isolation of material in a precise and location dependent-manner. The methods and compositions described herein may be used, for example, for biomarker discovery, identification of cell populations, pathology analysis, and generation of expression data in specific regions of interest.

Disclosed is a composite particle for use in a marking that is suitable for identification/authentication purposes. The particle comprises at least one superparamagnetic portion and at least one thermoluminescent portion coated with an thermoisolating portion. Optionally also a thermoconductive portion between the superparamagnetic and thermoluminscent portions.

Disclosed is a composite particle for use in a marking that is suitable for identification/authentication purposes. The particle comprises at least one superparamagnetic portion and at least one thermoluminescent portion coated with an thermoisolating portion. Optionally also a thermoconductive portion between the superparamagnetic and thermoluminscent portions.

The present application discloses an electrochemiluminescence (ECL) immunosensor. The ECL immunosensor includes an electrode modified by a nanocomposite comprising a mixture of carbon nanochips (CNCs); iron oxide (Fe.sub.3O.sub.4); and nafion (NAF). The electrode is a screen-printed electrode which further is a carbon screen-printed electrode (SPE). The carbon screen-printed electrode (SPE) is a mesoporous carbon screen-printed electrode (SPE). Ru(bpy).sub.3Cl.sub.2.6H.sub.2O is a luminophore and TPrA is a coreactant of the luminophore.