The embodiments disclosed herein provide a peptoid, which is a compound of Formula I or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof. N—R.sub.4, N—R.sub.3, N—R.sub.2, and N—R.sub.1 in Formula I are

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respectively. The peptoid has a strong binding ability with EGFR protein. It can be used not only for targeted treatment of diseases associated with EGFR protein, but also for imaging detection or prognosis monitoring of diseases associated with EGFR protein.

##STR00002##

Volatile organic chemicals emitted by a shell egg embryo are used to identify the fertility, viability, and sex of the shell egg embryo. Shortly after the egg is laid, the egg is isolated in a vapor-tight compartment so that a vapor containing volatile organic chemicals emitted by the shell egg embryo collect in the headspace of the compartment. The chemicals in the vapor are analyzed to construct a chemical profile of the shell egg embryo, and then the chemical profile of the shell egg embryo vapor is loaded into a previously developed model. Based on the data generated by the model, the shell egg is embryo is predicted to be an alive male, an alive female, an infertile egg, or an egg containing a dead embryo.

Volatile organic chemicals emitted by a shell egg embryo are used to identify the fertility, viability, and sex of the shell egg embryo. Shortly after the egg is laid, the egg is isolated in a vapor-tight compartment so that a vapor containing volatile organic chemicals emitted by the shell egg embryo collect in the headspace of the compartment. The chemicals in the vapor are analyzed to construct a chemical profile of the shell egg embryo, and then the chemical profile of the shell egg embryo vapor is loaded into a previously developed model. Based on the data generated by the model, the shell egg is embryo is predicted to be an alive male, an alive female, an infertile egg, or an egg containing a dead embryo.

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are transferred to a sample chamber where the captured gas is analyzed.

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are transferred to a sample chamber where the captured gas is analyzed.

An incubation tray is disclosed, including an enclosure with a plurality of egg placements for carrying eggs for incubation within an egg incubator. The incubation tray includes a tester unit including plurality of inspection modules in the enclosure associated with the plurality of egg placements. The inspection modules, each includes radiation emitter(s) and sensor(s), and are configured and operable for respectively inspecting the plurality of eggs located in the egg placements, by irradiating the eggs with radiation from a lateral side of the eggs and measuring a radiation response coming in response to the irradiation from a lateral side of the eggs, giving rise to measured data indicative of conditions of the eggs. The measured data may be processed to determine dynamic and static parameters of the radiation response from which a physiological development stage, and growth of the embryos within the eggs can be estimated.

The present invention relates to a method for spectroscopical in-ovo gender determination of fertilized and incubated bird eggs comprising the steps of:

a. providing a number of passages in an egg shell of an egg for allowing entrance into an interior of the egg and/or exit from the interior of the egg of electromagnetic waves suitable for spectroscopy,
b. introducing electromagnetic waves into the interior of the egg
c. detecting electromagnetic waves exiting the egg;
d. analysing, by spectroscopy, of the exiting electromagnetic waves at at least one passage of the number of passages; and e. determining the gender of a chicken embryo.

The present invention relates to a method for spectroscopical in-ovo gender determination of fertilized and incubated bird eggs comprising the steps of:

a. providing a number of passages in an egg shell of an egg for allowing entrance into an interior of the egg and/or exit from the interior of the egg of electromagnetic waves suitable for spectroscopy,
b. introducing electromagnetic waves into the interior of the egg
c. detecting electromagnetic waves exiting the egg;
d. analysing, by spectroscopy, of the exiting electromagnetic waves at at least one passage of the number of passages; and e. determining the gender of a chicken embryo.

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are transferred to a sample chamber where the captured gas is analyzed.

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are transferred to a sample chamber where the captured gas is analyzed.