G01N2201/062

System and method for in situ measuring and collecting samples of analyte concentration in bodily fluids

A system and related methods include a durable component, an indicator component including an indicator zone comprising at least one colorimetric analyte sensing element, at least one moisture sensor, and a fluid collection reservoir. The durable component contains at least one spectrophotometer, a computing system, and means for electronic communication between the computing system and at least one external device. The indicator component includes at least one colorimetric analyte sensing element and a fluid transport layer in fluid communication with the indicator zone, and it is arranged and configured for attachment to the durable component. In addition, the moisture sensor is arranged and configured to communicate the presence of moisture to initiate a predetermined delay in measuring the concentration of at least one analyte. The fluid collection reservoir is releasable from at least one of the indicator components and the durable component at a predetermined breaking point for clinical analysis.

Scanning Analyzer for Single Molecule Detection and Methods of Use
20230160825 · 2023-05-25 ·

The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

SYSTEM AND METHOD FOR IN-LINE OPTICAL SENSING OF HYDROGEN PEROXIDE

A water monitoring system comprising a hydrogen peroxide sensor configured to determine a concentration of hydrogen peroxide in water in a conduit. The hydrogen peroxide sensor further comprises an ultraviolet light sensor configured to determine an ultraviolet light absorbance level of the water in the conduit. The ultraviolet light absorbance level is used to determine the concentration of hydrogen peroxide. The hydrogen peroxide sensor may further comprise a visible light sensor configured to determine a turbidity level of the water in the conduit. The turbidity level also is used to determine the concentration of hydrogen peroxide.

OPTICAL MODULE
20230115210 · 2023-04-13 · ·

An optical module (100) for reading a test region of an assay. The optical module comprises: a first light source (101) for illuminating the test region of the assay; an optical detector (103), comprising an optical input for receiving light emitted from the test region and an electrical output; a substrate (104) for mounting the first light source (101) and the optical detector (103); and a housing (105) comprising: a first opening (106) for providing a first optical path from the first light source (101) to the test region (103); wherein the housing (105) and the substrate (104) enclose and positionally align the first source (101) and the optical detector (103) relative to the first opening (106). The housing (105) may comprise one or more legs (108), such as a flexible hook portion which secures the housing (105) to the substrate (104) with a snap-fit engagement, extending from a first and/or second outer surface of the housing (105) in a vertical direction. Beneficially, the snap-fit engagement provided by the flexible hook portion allows the housing to be aligned and secured without the need to use glue or for example a screw and thread that can be difficult to control and/or risks misalignment of the housing.

System and method for time-resolved fluoroimmunoassay detection
11467155 · 2022-10-11 · ·

A system for time-resolved fluoroimmunoassay detection is disclosed. The system comprises a receptacle with a sample volume adapted for receiving a sample therein; a light source adapted to emit pulsed excitation light illumination optics adapted to collect the pulsed excitation light from the light source and to deliver the pulsed excitation light to the sample volume in the receptacle; a detection device adapted for gated detection of fluorescence radiation at least in a detection spectral range; detection optics adapted to collect fluorescence radiation from the receptacle at least in the detection spectral range and deliver the fluorescence radiation to the detection device; and an optical filter device configured for the separation of excitation light and detection light. A method for time-resolved fluoroimmunoassay detection is also provided.

Light emitting and receiving apparatus and method of diagnosing deterioration
11467144 · 2022-10-11 · ·

A light emitting and receiving apparatus includes a controller and a calculator. The controller acquires a first detection current from a light-receiving element when supplying a first drive current to a light-emitting element and acquires a second detection current from the light-receiving element when supplying a second drive current to the light-emitting element. The calculator generates a signal indicating deterioration of the light-emitting element when a reference value and an aging value satisfy a deterioration judgment condition, the aging value being a ratio between the first detection current and the second detection current. The detection accuracy of the light emitting and receiving apparatus is thereby improved.

SENSING ARRANGEMENT AND CORRESPONDING DETECTOR DEVICE

The sensing arrangement (1), comprising:—a sensing area (10), for accommodating a sensing substance (20) selected for experimenting an optical response as a response of an external stimulus;—a light emitter (11), for emitting light towards said sensing area (10);—a light receiver (12), for receiving a light from said sensing area (10);—a substrate (13) having a first substrate surface (131) and a second substrate surface (132); wherein, said light emitter (11) comprise a first LED (110) and said light receiver (12) comprise a second LED (120), both LEDs (110, 120) formed on said first substrate surface (131); and said sensing arrangement (1) further comprises a trench (14), formed between said first LED (110) and said second LED (120).

Phosphorescence oxygen analyzer and uses thereof
11467151 · 2022-10-11 · ·

The phosphorescence oxygen analyzer has a light source including an LED array that flashes light at 1,000 flashes per second. The light flashes are received in a test chamber containing a carousel having a plurality (preferably ten) of sample vials mounted thereon. The samples a phosphorescent probe (palladium(II) complex, namely, meso-tetra-(4-sulfonatophenyl)tetrabenzoporphyrin; Pd phosphor) mixed with either a control sample of tissue or a sample of tissue and a suspected toxin or a pharmaceutical it is desired to test, the carousel being rotated to irradiate each vial in turn. The probe has an absorption maximum at 625 nm and emission maximum at 800 nm. Phosphorescent emissions are detected by a photomultiplier tube connected to a measurement 2020 board, which is connected to a processor that computes the lifetime and peak of the pulses, which determines the rate of phosphorescent decay due to oxygen metabolized by the tissue mitochondria.

DEVICE FOR OPTICALLY IDENTIFYING SURFACES
20230105753 · 2023-04-06 · ·

A device for optically identifying surfaces, in particular for optically identifying structured and/or pictorial surfaces, spaces and/or e.g. paintings or sculptures is simple to use independently of the location. For this purpose, the device includes a housing in which light-emitting and light-receiving elements are arranged, and the device also includes a first portion having at least one lens, a portion that follows the first portion in the longitudinal direction and has a screen, and an adjoining handle portion.

INSPECTION SYSTEM FOR QUALITY ANALYSIS OF A PRODUCT TO BE INSPECTED

The invention relates to an inspection system for quality analysis of a food product, comprising conveyance means for moving it to an inspection area, a lighting device consisting of LEDs that emit a light sequence directed towards the inspection area to light up the product by transmission, a linear camera with at least one line of pixels for collecting a plurality of images in each light sequence of the lighting device, and focusing means for focusing the beam emitted by the lighting device. Advantageously, the lighting device is activated in a pulsed manner, generating a light sequence with at least two different illuminations, at least one of which is a transmission-pulsed illumination. The lighting device is aligned on the axis formed by the product to be inspected and the linear camera.