A system for detecting analytes in a test sample, and a method for processing the same, is provided. The system includes a cartridge reader unit that has a control unit and a pneumatic system, and a cartridge assembly that prepares the samples with mixing material(s) through communication channels. The assembly has a memory chip with parameters for preparing the sample and at least one sensor. The assembly, pneumatic system, and control unit operate together to prepare the sample and provide the prepared sample to the sensor for detecting analytes, and also process measurements from the sensor to generate test results.

A magnetic particle imaging system includes a field free region generator and an excited magnetic field generator. The field free region generator generates a field free line with a direction of linear extension of a field free region as a direction of extension. The excited magnetic field generator generates an excited magnetic field in the field free line generated by the field free region generator. The excited magnetic field generator includes a first excited magnetic field generation unit and a second excited magnetic field generation unit. The first excited magnetic field generation unit and the second excited magnetic field generation unit are spaced from each other in the direction of extension of the field free line.

Aspects of this disclosure relate to one or more particles that move within a container in response to a magnetic field. A measurement circuit is configured to output an indication of the magnetic field based on position of the one or more particles.

Some examples herein provide methods for determining a sequence of a nucleic acid template hybridized to a complementary strand. A polymerase coupled to a magnetically-responsive sensor may capture the nucleic acid template hybridized to the complementary strand. The polymerase and the captured nucleic acid template hybridized to the complementary strand may be contacted with a first fluid comprising a nucleotide. The polymerase may incorporate the nucleotide into the complementary strand based on the sequence of the nucleic acid template. The polymerase and the captured nucleic acid template hybridized to the complementary strand, including the incorporated nucleotide, may be contacted with a second fluid comprising a magnetic particle. The incorporated nucleotide may capture the magnetic particle from the second fluid. The captured magnetic particle may cause a change in electrical resistance at the magnetically-responsive sensor. The change in electrical resistance may be used to identify the incorporated nucleotide.

Disclosed herein is a nano-magnetic-particle-imaging apparatus, including a measurement head including excitation and detection coils and accommodating a sample bed for a sample including nano magnetic particles; a gradient magnetic field generation unit for generating a magnetic field having a strength equal to or greater than that of the saturation magnetic field of the nano magnetic particles in a spacing area between identical magnetic poles facing each other and forming a field-free region in a portion thereof; a first driving unit for linearly moving the sample bed; a second driving unit for rotating the gradient magnetic field generation unit in a plane; a third driving unit for linearly reciprocating the gradient magnetic field generation unit; and a control unit for applying a signal to the excitation coil, controlling the driving units, and imaging 3D distribution of the nano magnetic particles based on a detection signal output from the detection coil.

A method for reading a lateral flow assay test strip comprises providing a microwave antenna in proximity of a stain line region of the test strip. The method includes causing a chemical compound to travel to the stain line region, an amount of the chemical compound varying in accordance with a quantity of an analyte. The method comprises connecting an instrumentation to the microwave antenna. The method includes measuring a feed impedance of the microwave antenna using the instrumentation, the feed impedance of the microwave antenna varying with the amount of the chemical compound. The method comprises determining the quantity of the analyte based on the feed impedance of the microwave antenna.

Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.

A physically unclonable function is an object that has characteristics that make it extremely difficult or impossible to copy. An array of randomly dispersed hard (magnetized) and soft (non-magnetized) magnetic particles that may be conducting or nonconducting that are disbursed in a binder create a particular magnetic field or capacitive pattern on the surface. This surface magnetic field and capacitive variations can be considered to be a unique pattern similar to fingerprint. The Hall effect prism is a sensor that measures the effects of these patterns by sensing the deformation of currents or electric potential flowing within or around a resistive substrate material that exhibits a substantial Hall effect coefficient.

Example embodiments of the present invention provide a magnetic relaxometry measurement apparatus, comprising: a magnetizing system configured to supply a pulsed magnetic fields to a sample; a sensor system configured to detect magnetic fields produced by induced magnetization of the sample after a magnetic field pulse from the magnetizing system; one or more compensating coils configured to suppress generation of eddy currents in an environment surrounding the apparatus due to the pulsed magnetic fields.

A magnetic induction molecular imaging method and a magnetic induction molecular imaging system for biological tissue detection, comprises a detection bed, a magnetic nanoparticle device, a magnetic field generating device, a signal receiving and transmitting device, a magnetic field signal acquisition device and computer equipment, wherein the magnetic nanoparticle device is used for sending magnetic nanoparticles to a to-be-detected area of the detection bed; the magnetic field generating device is used for generating and transmitting electromagnetic waves to the signal receiving and transmitting device; the signal receiving and transmitting device is used for receiving the electromagnetic waves transmitted by the magnetic field generating device; the magnetic field signal acquisition device is used for acquiring scattered electric field information and scattered magnetic field information, based on the magnetic nanoparticles, of the to-be-detected area detected by each sensor on sensor arrays.