A method of sensing molecules using a detection device, the detection device comprising a plurality of magnetoresistive (MR) sensors and at least one fluidic channel, comprising adding a plurality of molecules to be detected to the at least one fluidic channel, wherein at least some of the plurality of molecules to be detected are coupled to respective magnetic nanoparticles (MNPs), detecting a characteristic of a magnetic noise of a first MR sensor of the plurality of MR sensors, wherein the characteristic of the magnetic noise is influenced by a presence of one or more MNPs in a vicinity of the first MR sensor, and determining, based on the detected characteristic, whether the first MR sensor detected the presence of one or more MNPs in the vicinity of the first MR sensor.

A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field with a field free line, the magnet integrated with a flux return designed so that a flux path at approximately the center of the field-free line has a first reluctance and a second flux path distal from the center of the field-free line has a second reluctance, and the second reluctance is lower than the first reluctance to facilitate a high fidelity magnetic field and high fidelity field free line.

A cartridge assembly, and method of using the same, is provided. The assembly includes a sample processing card and a substrate attached thereto. The card has an injection port for receiving a test sample; at least one metering chamber; a mixing material source for introducing mixing material(s) to the metering chamber; fluid communication channels fluidly connecting the injection port and the mixing material source to the metering chamber; and at least one output port for delivering the test sample to a sensor (e.g., GMR sensor). The substrate has associated therewith: the sensor for sensing analytes in the test sample; electrical contact portions for an electrical connection with a reader unit; and a memory chip. The assembly further includes a pneumatic interface with port(s) and corresponding communication channel(s) fluidly connected to card. The interface connects with an off-board pneumatic system and enables application of positive and negative pressurized fluid to the card to move the test sample and one or more mixing materials therein and to the sensor.

Provided is an electromagnetic device for magnetic particle imaging, including: a return yoke having a gap, which extends in a Y direction and forms a magnetic field space; a gradient magnetic field generating unit, which is provided to the return yoke, and is configured to generate, in the magnetic field space, a gradient magnetic field in an X direction, and to form, in the magnetic field space, a zero-field region extending in the Y direction; an alternating magnetic field generating unit, which is provided to the return yoke, and is configured to generate an alternating magnetic field in the magnetic field space; and a rotation mechanism configured to rotate the gradient magnetic field and the alternating magnetic field relative to a subject with a Z direction being a rotation axis.

The invention relates to a method for detecting and/or identifying magnetic supraparticles using magnet particle spectroscopy (MPS) or magnet particle imaging (MPI), wherein magnetic supraparticles are provided, each of which contains a plurality of magnetic nanoparticles and which have a specific composition and/or structure. The magnetic supraparticles are exposed to at least one magnetic field, whereby at least one voltage and/or a voltage curve is induced based on the magnetic moment of the magnetic supraparticles. The at least one voltage and/or the voltage curve is detected as at least one measurement signal, and at least one spectrum is generated from the at least one measurement signal, said spectrum containing harmonics, each of which has an amplitude and a phase. The magnetic supraparticles are (uniquely) detected and/or identified using the at least one generated spectrum.

The invention relates to a method for carrying out signal detection by means of magnetic particle imaging, in which method magnetic/magnetisable particles (4), arranged in the field-free region of a location-dependent magnetic field, in particular a gradient magnetic field, are magnetised by means of an excitation magnetic field that changes over time, and the harmonics (9, 15), generated by the particles (4), of the frequency of the excitation magnetic field are detected as a signal from the magnetic particles (4) by means of a receiver coil arrangement (1) which in particular surrounds the particles (4), wherein a signal-transmitting arrangement, which has an outer coil (10) and at least one inner coil (11; 16, 17) connected in series to said outer coil, is positioned within the receiver coil arrangement (1) around the particles (4), wherein the signal received from the particles (4) by the at least one inner coil (11; 16, 17) is transmitted to the outer coil (10) by current flow and is re-emitted by said outer coil, in particular as a result of which the signal (S) received directly from the particles (4) and the signal (S) received from the particles (4) indirectly by the outer coil (10) are superimposed at the receiver coil arrangement (1). The invention also relates to a signal-transmitting arrangement for a magnetic-particle-imaging scanner/spectrometer, comprising an outer coil (10) which in particular has a smaller diameter than the sample-receiving channel (2) of the scanner/spectrometer, and comprising at least one inner coil (11; 16, 17) which is arranged in the outer coil (10), preferably arranged coaxially therein, and in particular has greater diameter than a sample to be examined, wherein the outer coil (10) and the inner coil (11; 16, 17) are electrically connected in series. The invention also relates to a system comprising a magnetic-particle-imaging scanner and a signal-transmitting arrangement.

A magnetic sensor array device is described that is constructed with multiple single sensor die, diced out of a wafer as a group and packaged in a wafer level package (WLP). The device comprises an array of multi-axis magnetic sensors that can measure the multi-dimensional magnetic field of an arbitrary sized two-dimensional region with high spatial resolution, reduced sensing distance, higher measurement throughput, tolerance to motion, improved temperature measurement, and improved yield when placed on a circuit card comprises part of an authentication system including a physical unclonable function (“PUF”), a substrate, a plurality of magnetized particles randomly dispersed in the substrate, and a PUF reader constructed using one or more of the magnetic sensor array devices wherein the PUF reader measures the magnetic field at multiple locations in close proximity to the magnetized particles. The measured magnetic field data may be compared to previously enrolled data to assess authenticity.

A system for one-sided measuring a presence of magnetic particles in a probe volume comprises a one-sided coil assembly and a current controller, wherein the one-sided coil assembly is arranged around a central coil assembly axis for generating a rotating magnetic field distribution and comprises at least 3, preferably at least 4, circumferentially distributed coil assembly sectors, wherein the current controller is configured to generate a time varying current in each of said coil assembly sectors, said time varying current comprising a periodic modulation with a rotation frequency and phase shifted between adjacent coil assembly sectors to generate a magnetic field rotating in a plane perpendicular to the coil assembly axis, said magnetic field rotating with a rotation frequency associated with a frequency of said periodic modulation, and wherein the system is configured for measuring said presence of magnetic particles in said probe volume with said one-sided coil assembly.

Methods for the detection of enzymatic activity, in particular, to in vivo methods. A non-invasive method for in vivo enzyme activity detection, such as activity of proteinases, to substrates specifically developed for these methods and to a device detecting product formation of the enzyme to be tested based on determination of signals produced by the substrates and/or its products.

A tracer composition includes a carrier fluid and a tracer particle that includes at least one magnetic material and an acoustic signal generating material. A method includes introducing a tracer composition into a reservoir at a first location. The method further includes collecting fluid from the reservoir at a second location, where the first location is different from the second location. The method also includes applying a magnet field to the fluid collected from the reservoir such that the magnetic material produces vibrational energy. Due to the vibrational energy generated in the magnetic material, thermal energy is transferred to the acoustic signal generating material thereby heating the acoustic signal generating material to a boiling point such that the acoustic signal is generated. The method further includes detecting the acoustic signal and correlating the acoustic signal to a tracer particle concentration.