Aspects of photonic band gap resonators for magnetic resonance are described. In one example, an apparatus includes a 1D structure having a plurality of layers. A respective thickness of the individual layers is one-quarter of a respective wavelength of a target magnetic resonance frequency within the individual layers of the plurality of layers, or a multiple thereof. A first layer has a first dielectric constant, and a second layer that is adjacent to the first layer has a second dielectric constant. A defect includes a sample. The defect has a thickness that is approximately up to one-half of a wavelength of the target magnetic resonance frequency within the defect.

A method of hyperpolarizing diamond particles includes applying a laser to a sample of the diamond particles, irradiating the diamond particles with a sweeping microwave to cause diamond polarization, shuttling the diamond particles through a magnetic field to detect .sup.13C nuclei in the diamond particles, and relaying the diamond polarization to nuclear spins to one of a surrounding solid or fluid.

A composition is provided. The composition includes a magnetic resonance (MR) probe and a glassification agent. The glassification agent includes lactic acid.

A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent described herein and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the polarizing agent; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. In certain embodiments, the polarizing agents can be peptide-based. In these embodiments, the polarizing agents can be readily prepared by solid-phase peptide synthesis.

Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent described herein and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the polarizing agent; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. In certain embodiments, the polarizing agents can be peptide-based. In these embodiments, the polarizing agents can be readily prepared by solid-phase peptide synthesis.

The nuclear spin hyperpolarization method includes the steps of: irradiating a sample, prepared by doping solid benzoic acid derivative with a pentacene derivative, placed in a space where a static magnetic field is formed by a main magnetic field forming unit, with a laser beam from a laser source; following the light irradiation, irradiating the sample with a microwave from a microwave source while applying a sweeping magnetic field; and after repeating the application of sweeping magnetic field, light irradiation and microwave irradiation, dissolving the benzoic acid derivative in the sample. This enables generation of an aqueous solution containing benzoic acid derivative of which nuclear spins are hyperpolarized.

The nuclear spin hyperpolarization method includes the steps of: irradiating a sample, prepared by doping solid benzoic acid derivative with a pentacene derivative, placed in a space where a static magnetic field is formed by a main magnetic field forming unit, with a laser beam from a laser source; following the light irradiation, irradiating the sample with a microwave from a microwave source while applying a sweeping magnetic field; and after repeating the application of sweeping magnetic field, light irradiation and microwave irradiation, dissolving the benzoic acid derivative in the sample. This enables generation of an aqueous solution containing benzoic acid derivative of which nuclear spins are hyperpolarized.

A wearable blood analyte measurement device includes a casing defining an appendage—receiving bore and having an interior volume. A plurality of magnets is within interior volume. The magnets produce a magnetic field in the bore. A nuclear magnetic resonance (NMR) transceiver is supported by the casing and positioned to emit radiofrequency (RF) pulses to and receive NMR signals from the bore. An electronics assembly is within the interior volume and in communication with the NMR transceiver. A power source is in the interior volume and powers the NMR transceiver and the electronics assembly.