Systems and methods for relative optimized linearization (ROL) for radiochromic film (RCF) dosimetry may eliminate the need for dose-response curve measurements while incorporating non-uniformity corrections. The ROL method may include, for each of multiple color channels, determining linearization parameters that minimize a cost function that evaluates an error between expected and calculated doses. The ROL method may use the linearization parameters to generate a variation map including dose-independent variation values and use the variation map to determine a corrected net optical density of the RCF. The ROL method may use the linearization parameters and the corrected net optical density to produce a dose image including corrected doses.