The disclosure relates to a method for making carrier for use in single molecule detection. The method includes: providing a rigid substrate; coating a polymer layer on a surface of the rigid substrate, the polymer layer is in semisolid state; transferring a nano-scaled pattern of a template on a surface of the polymer layer by pressing the template on the surface of the polymer layer; obtaining a flexible substrate by removing the template; and applying a metal layer on the flexible substrate. The carrier for use in single molecule detection has a relative higher SERS and can enhance the Raman scattering.

Described herein is a receptacle for holding a sample under spectrophotometer analysis comprising: a body, first and second opposing windows separated by a gap to provide a volume for a sample, wherein at least the first opposing window is supported by a first compliant member, and wherein under a force, the first compliant member allows positioning of the first opposing window relative to a first datum to set a desired: a) gap between the first and second opposing windows, and/or b) relative orientation of the first and second opposing windows.

A flow cell assembly (16) for a fluid analyzer (14) that analyzes a sample (12) includes (i) a base (350) that includes a base window (350B); (ii) a cap (352) having a cap window (352B) that is spaced apart from the base window (350B); and (iii) a gasket (360) that is secured to and positioned between the base (350) and the cap (352), the gasket (360) having a gasket body (360A) that includes a gasket opening (360B). The gasket body (360A), the base (350) and the cap (352) cooperate to define a flow cell chamber (362). Moreover, an inlet passageway (366) extends into the flow cell chamber (362) to direct the sample (12) into the flow cell chamber (362); and an outlet passageway (368) extends into the flow cell chamber (362) to allow the sample (12) to exit the flow cell chamber (362).

A transmitted light intensity measurement unit for measuring a concentration of fluid flowing through a duct comprises: a light source for supplying light into the duct from a light supply part on a surface of the duct; a light receiving element for receiving the light, which has been passed from the light supply part through the duct wall and the fluid inside the duct, at a light receiving part located on an opposite side in a diametrical direction of the duct relative to the light supply part, and outputs a signal indicating an intensity of the light; and a light-transmissive member disposed on at least one light path among a light pass between the light source and the light supply part and a light pass between the light receiving element and the light receiving part, abutting and closely contacting the duct wall by an elastic deformation of the duct wall.

An analyte detection package includes a chamber, a surface-enhanced luminescence analyte stage within the chamber, and a tunable lens integrated with the package to focus radiation onto the analyte stage.

This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A measuring system is provided having: a base unit with a means for locating a pipette tip; a pipette tip designed to interact with the base unit for purposes of accurate pipette tip positioning; at least one light supplying unit positioned to supply light to a liquid sample in the pipette tip and at least one light collecting unit positioned to collect light from a liquid sample in the pipette tip.

An optical waveguide comprises multiple layers of solid-state material disposed on a substrate. One of the layers is a lifting-gate valve made of a high refractive index material. The device provides for better optical confinement in microfluidic channels, and has the capability to integrate both optical signals and fluid sample processing. The optical paths on the chip are reconfigurable because of the use of a movable microvalve that guides light in one of its positions.

A system and method for measuring a concentration of a gas in a container having at least one flexible or variable side or wall. The system and method comprising creating a determinable optical path length through the container having a shape. Positioning a light source head and a detector head against at least one of the least one flexible or variable side or wall. Transmitting a light signal between the light source head and the detector head through the determinable optical path length. Determining the concentration of the gas in the container based on detected light and the determinable optical path length.

A transmitted light intensity measurement unit for measuring a concentration of fluid flowing through a duct comprises: a light source for supplying light into the duct from a light supply part on a surface of the duct; a light receiving element for receiving the light, which has been passed from the light supply part through the duct wall and the fluid inside the duct, at a light receiving part located on an opposite side in a diametrical direction of the duct relative to the light supply part, and outputs a signal indicating an intensity of the light; and a light-transmissive member disposed on at least one light path among a light pass between the light source and the light supply part and a light pass between the light receiving element and the light receiving part, abutting and closely contacting the duct wall by an elastic deformation of the duct wall.

A system and method for measuring a concentration of a gas in a container having at least one flexible or variable side or wall. The system and method comprising creating a determinable optical path length through the container having a shape. Positioning a light source head and a detector head against at least one of the least one flexible or variable side or wall. Transmitting a light signal between the light source head and the detector head through the determinable optical path length. Determining the concentration of the gas in the container based on detected light and the determinable optical path length.