The present invention relates assembly and a system for improved, high-throughput cost-effective cell culture, cultivations, fermentations and assays. Taking advantage of an assembly which can adopt two different configurations, efficient methods for monitoring a plurality of reaction systems and/or for cultivating and/or screening cell populations are provided.

A process conducted in a rocking bioreactor is monitored using a flexible bag fitted with an in-situ probe. The probe includes a disposable bag insert or patch and a reusable probe module. The patch is secured to a wall of the bag, and the probe module is a detachable part that can be mated to the bag patch, then disassembled for future use, for example. The patch is secured to the bag, defining a sample gap, and the probe module is inserted or mated with the patch. The probe module includes one or more source elements and one or more detector element. Light is transmitted from the source elements, through the sample gap, to the detector element(s), which detect the light after interaction with contents of the bag.

A system includes a cuvette including a cuvette body forming a substantially planar exterior surface and having a sensor window defined within the substantially planar exterior surface. The cuvette further includes a probe retention structure extending from the cuvette body. The system includes a probe with a probe body and a protrusion that is removably coupled to the probe retention structure.

Systems and methods for performing measurements of one or more materials are provided. One system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels. Another system is configured to image one or more materials in an imaging volume of a measurement device. An additional system is configured to substantially immobilize one or more materials in an imaging volume of a measurement device. A further system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels, to image the one or more materials in the imaging volume, to substantially immobilize the one or more materials in the imaging volume, or some combination thereof.

A device for monitoring at least one parameter of a fluid specimen obtained from a patient. The device has a fluid conduit holder comprising a clamp configured to position a fluid conduit, which holds the fluid specimen obtained from the patient, in a position for optical analysis, and an optical analyzer having a light source and a light detector. The optical analyzer is configured to expose the fluid specimen contained within the fluid conduit to an illuminant and measure light received at the detector. The device has an optical alignment mechanism mechanically coupling the light source, the clamp, and the light detector together, and configured to align at least the light detector with the fluid conduit at the position for optical analysis.

A spectrometer apparatus for measuring spectra of a liquid sample, such as a beverage like wine. The apparatus has an integrating cavity with a reflective inner wall to receive a cuvette containing the liquid sample within the integrating cavity. A combination of light inlet ports and light outlet ports are provided to receive light from at least one light source and deliver light to a spectrometer. A light path adjuster is configured to selectively adjust a light path through the integrating cavity so at least two distinct light paths are provided wherein when the light path adjuster is in a first configuration, the apparatus is in transmission mode in which light from the light source follows a first light path; when the light path adjuster is in a second configuration, the apparatus is in a diffusely reflecting mode in which light from the light source follows a second light path.

This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A method and device for photometric measurement of liquids. The method includes the steps of: The method includes the steps of; providing a pipette tip, the pipette tip being made of an optically clear body having an outer wall and an inner wall, the inner wall defining an inner space for receiving a liquid sample, the inner space providing a cross-sectional path length for light; positioning the pipette tip between a light source and a light collector; measuring light transmission through the liquid sample; adjusting the inner space of the pipette tip to change the cross-sectional length, and measuring light transmission through the liquid sample. This can be accomplished by moving the light source from a first position to at least a second position to provide a plurality of cross-sectional path lengths through the liquid sample or by moving the pipette tip from a first position to at least a second position to provide a plurality of cross-sectional path lengths through the liquid sample.

An optical spectrometer module for analysing samples. The optical spectrometer module comprises two or more sample holders. Each sample holder is adapted to receive and reproducibly position a sample in fixed locations within the optical spectrometer module. Each sample holder is also adapted to receive a light beam to thereby enable a sample contained in the sample holder to be exposed to the received light beam. Each sample holder is further adapted to enable light transmitted through the sample holder to exit the sample holder. The optical spectrometer module also comprises two or more electro-thermal components. Each electro-thermal component is thermally coupled to a respective sample holder to control the temperature of the sample holder.

Disclosed is a process photometer arrangement (10) with a photometric cuvette unit (20) comprising a cuvette body (24) defining a cuvette cavity (25) and a combined sample inlet/outlet opening (34), a photometer light inlet window (60) and a photometer light outlet window (62). The cuvette body (24) is movably supported by a cuvette body support element (88) and the cuvette unit (20) is provided with a cuvette vibration device (80) for vibrating the cuvette body (24) to thereby quickly and homogenously mix a liquid sample volume (31) within the cuvette cavity (25) without any separate mixing element within the cuvette cavity. This allows a short mixing action within a microfluidic cuvette.

A transmissive sampling module is provided, which is adapted to a spectrometer main body. The transmissive sampling module includes a light source assembly and a support base. The light source assembly is directly connected to the support base. The support base includes a tube body and at least one fixing member. The tube body surrounds an accommodating groove, and an extending direction of the tube body is not parallel to an optical path of the light source assembly, and the tube body includes a transparent portion, and the optical path of the light source assembly passes through the transparent portion and the accommodating groove. The at least one fixing member is disposed on the tube body and is adjustably protruded out of an inner surface of the tube body. A transmissive spectrometer is also provided.