A structural color changeable material includes a strain body and surface plasmon generating particles. In the strain body, a strain is produced by an external pressure or an internal change. The surface plasmon generating particles generate surface plasmon and are contained in the strain body. The surface plasmon is generated by an incident light with a wavelength of 2400 nm or less. A mean particle size of the surface plasmon generating particles is equal to or less than the wavelength of the incident light. The surface plasmon generating particles are periodically arranged parallel to an in-plane direction of a reflection surface of the incident light.

This disclosure relates to a multiplex diagnostic method and related kits thereof for detecting the presence of different target analytes in a sample, the method comprising providing the sample and a plurality of reporter particles such as gold nanoparticles having different colours to a substrate, the substrate having a assigned spatial regions; and determining, on the substrate, the presence of a colour arising from the reporter particles in each of assigned spatial regions on the substrate, wherein each of the assigned spatial regions on the substrate is configured to immobilize a target analyte that is different from the other assigned spatial regions, wherein reporter particles of each different colour are configured to couple to a target analyte that is different from the reporter particles of the other different colours, and wherein is an integer that is at least two and is an integer that is at least two. In one embodiment, the reporter particles are configured to give rise to a secondary colour when reporter particles of two or more different colours are colocalized in the same spatial region, wherein the secondary colour resulting from the colocalization of the reporter particles of two or more different colours from the different colours is distinct from another secondary colour resulting from the colocalization of reporter particles of other combinations of colours from the different colours.

The present invention relates to a nanoplasmonic sensor based on gold nanoparticle to which an antibody or an aptamer binds, the antibody or the aptamer recognizing A 1-40, A 1-42, and protein, which are Alzheimer's disease onset markers that are present in blood, and a multi-detection method of Alzheimer's disease using Rayleigh scattering phenomenon and colorimetric assay of the sensor. The present invention has advantages in that it is possible to perform simultaneous multiple detect with respect to various onset markers by using a simple diagnosis method using blood, and sensitivity of diagnosis is improved by using a chaotropic solvent.

A method of designing a nanostructure, comprises: receiving a far field optical response and material properties; feeding the synthetic far field optical response and material properties to an artificial neural network having at least three hidden layers; and extracting from the artificial neural network a shape of a nanostructure corresponding to the far field optical response.

The subject matter of this specification can be embodied in, among other things, a graphene plasmon resonator that includes a planar patterned layer having a collection of electrically conductive segments, and a collection of dielectric segments, each dielectric segment defined between a corresponding pair of the electrically conductive segments, a graphene layer substantially parallel to the planar patterned layer and overlapping the collection of electrically conductive segments, and a planar dielectric layer between the planar patterned layer and the graphene layer.

This invention demonstrates that silver nanoparticles can be synthesized by reducing silver nitrate with sodium borohydride in a presence of surface stabilizer polystyrene-block-poly(2-vinyl pyridine) in order to overcome the aggregation of silver nanoparticles.

A sensing device includes an optical waveguide substrate and a plurality of biological probes. The optical waveguide substrate includes a light input end and a light output end. A plurality of biological probes are arranged and aligned on the optical waveguide substrate along a direction from the light input end to the light output end. The plurality of biological probes respond to different resonance wavelengths along the direction corresponding to different analytes. The present disclosure further includes a biosensing system including the sensing device.

A memristor-reconstructed near-infrared SPR biosensor with adjustable penetration depth includes a prism unit, a first non-conductive dielectric film layer, a metal film layer, a second non-conductive dielectric film layer and a conductive dielectric film layer, wherein the prism unit is configured to generate an ATR (Attenuated Total Reflection) attenuation evanescent wave; the first non-conductive dielectric film layer, the metal film layer, and the second non-conductive dielectric iv film layer define a sensing unit for achieving a basic sensing function; the metal film layer, the second non-conductive dielectric film layer and the conductive dielectric film layer define a memristive unit; a voltage applying device is provided between the first electrode and the second electrode for applying a bias voltage to the memristive unit so as to realize infrared memristive reconfiguration. A preparation method and a is penetration depth tuning method of the memristor-reconstructed near-infrared SPR biosensor with adjustable penetration depth are also disclosed.

A chemical analyte sensor. The sensor has a monolayer of shaped nanostructures, a metal or metallized surface, and analyte confined between the monolayer of shaped nanostructures and the metal or metallized surface. The analyte is confined in the highly absorbing optical cavity of the metasurface defined at the metal or metallized surface.

A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.