This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring α-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing α-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four-wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the α-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the α-synuclein in the fluidic sample.

The present invention relates to a real-time detection device for municipal solid waste components in an incinerator. The real-time detection device includes: an optical fiber sensor, which faces combustion flame of municipal solid waste combustion region through an observation hole in the incinerator; a spectrometer, which is used for receiving optical signal of the optical fiber sensor; an industrial personal computer, which is used for receiving data of the spectrometer and outputting the municipal solid waste components according to a municipal solid waste component detection program; the municipal solid waste component detection program obtains combustion flame spectral information of municipal solid waste in the incinerator by utilizing the optical fiber sensor and the spectrometer, and detects the municipal solid waste components in real time based on combustion flame spectrum of a single waste component. The present invention further relates to a real-time detection method for municipal solid waste components in an incinerator. Compared with manual classified sampling and detection, the device and method provided by the present invention have the advantages of high efficiency, rapidness, accuracy, capability of being updated in real time; and can realize stable combustion of the municipal solid waste in the incinerator, and reduce emission of pollutants and realize efficient and clean utilization of the municipal solid waste.

The present invention relates to a real-time detection device for municipal solid waste components in an incinerator. The real-time detection device includes: an optical fiber sensor, which faces combustion flame of municipal solid waste combustion region through an observation hole in the incinerator; a spectrometer, which is used for receiving optical signal of the optical fiber sensor; an industrial personal computer, which is used for receiving data of the spectrometer and outputting the municipal solid waste components according to a municipal solid waste component detection program; the municipal solid waste component detection program obtains combustion flame spectral information of municipal solid waste in the incinerator by utilizing the optical fiber sensor and the spectrometer, and detects the municipal solid waste components in real time based on combustion flame spectrum of a single waste component. The present invention further relates to a real-time detection method for municipal solid waste components in an incinerator. Compared with manual classified sampling and detection, the device and method provided by the present invention have the advantages of high efficiency, rapidness, accuracy, capability of being updated in real time; and can realize stable combustion of the municipal solid waste in the incinerator, and reduce emission of pollutants and realize efficient and clean utilization of the municipal solid waste.

A laser-heterodyne combustion-efficiency monitor captures light emitted from a combustion zone during combustion and determines combustion efficiency based on the captured light. The monitor includes an optical detector that generates an electrical response by mixing the captured light with an optical local-oscillator signal, and a signal filter that filters the electrical response to isolate a beat-note that is proportional to a target-species concentration in the combustion zone. The frequency of the local-oscillator signal determines the target species, which may be carbon monoxide, carbon dioxide, or another emission or absorption line that can be detected using laser-heterodyne radiometry. A laser generates the local-oscillator signal. The monitor may be extended to operate with several lasers emitting several local-oscillator signals at different frequencies, thereby allowing multiple target species to be detected simultaneously.

A laser-heterodyne combustion-efficiency monitor captures light emitted from a combustion zone during combustion and determines combustion efficiency based on the captured light. The monitor includes an optical detector that generates an electrical response by mixing the captured light with an optical local-oscillator signal, and a signal filter that filters the electrical response to isolate a beat-note that is proportional to a target-species concentration in the combustion zone. The frequency of the local-oscillator signal determines the target species, which may be carbon monoxide, carbon dioxide, or another emission or absorption line that can be detected using laser-heterodyne radiometry. A laser generates the local-oscillator signal. The monitor may be extended to operate with several lasers emitting several local-oscillator signals at different frequencies, thereby allowing multiple target species to be detected simultaneously.

Process for measuring emission for a flame in an open combustion environment. A captured image is received from each of a plurality of image capturing devices in at least one selected spectral band. Each of the plurality of image capturing devices is trained on the flame from the combustion process from a different perspective view angle. A spectral path length of the flame in the at least one spectral band is estimated from the captured images. Emitted radiance of the flame is estimated from the captured images, and a temperature of the flame is estimated from the estimated emitted radiance. A gas species concentration of the flame is estimated from the temperature of the flame and the spectral path length of the flame. Emission for the flame is measured from the gas species concentration.

Process for measuring emission for a flame in an open combustion environment. A captured image is received from each of a plurality of image capturing devices in at least one selected spectral band. Each of the plurality of image capturing devices is trained on the flame from the combustion process from a different perspective view angle. A spectral path length of the flame in the at least one spectral band is estimated from the captured images. Emitted radiance of the flame is estimated from the captured images, and a temperature of the flame is estimated from the estimated emitted radiance. A gas species concentration of the flame is estimated from the temperature of the flame and the spectral path length of the flame. Emission for the flame is measured from the gas species concentration.

A device for simultaneously measuring mercury, cadmium, zinc, and lead is provided, including: a gas generating device; a quartz analysis tube connected to the gas generating device, and the quartz analysis tube includes a sample heating zone, a high-temperature packing zone and a quartz collimating tube; an atomic absorption detection device AA1 arranged behind the quartz analysis tube, where the atomic absorption detection device includes an atomic absorption detector, a flame, and a light source; a quartz catalytic tube arranged behind the atomic absorption detection device, where the quartz catalytic tube includes a flame buffer zone and an adsorption packing zone; and an atomic absorption mercury measuring device arranged behind the quartz catalytic tube, where the atomic absorption mercury measuring device includes a mercury enrichment tube, an atomic absorption detector AA2 and an air pump.

A device for simultaneously measuring mercury, cadmium, zinc, and lead is provided, including: a gas generating device; a quartz analysis tube connected to the gas generating device, and the quartz analysis tube includes a sample heating zone, a high-temperature packing zone and a quartz collimating tube; an atomic absorption detection device AA1 arranged behind the quartz analysis tube, where the atomic absorption detection device includes an atomic absorption detector, a flame, and a light source; a quartz catalytic tube arranged behind the atomic absorption detection device, where the quartz catalytic tube includes a flame buffer zone and an adsorption packing zone; and an atomic absorption mercury measuring device arranged behind the quartz catalytic tube, where the atomic absorption mercury measuring device includes a mercury enrichment tube, an atomic absorption detector AA2 and an air pump.

An information processing apparatus includes information acquisition means configured to acquire quantitative information on a test substance, which is estimated by inputting spectrum information of a sample including the test substance into a learning model, and degree-of-contribution acquisition means configured to acquire a degree of contribution of the acquired quantitative information on the test substance.