Patent classifications
G01N2030/77
AN ELECTRON CAPTURE DETECTOR OPERATING WITH A SCINTILLATION CRYSTAL
The invention relates to a detector (100) which comprises at least one data output line (1) in connection with an electronic mechanism (200), at least one column input (2), which is connected to the detector outlet column of a gas chromatography device and to which the sample from which the chromatography data is to be obtained is sent, at least one gas inlet (3) so that preferably nitrogen gas can enter, at least one gas outlet (4) for gas to exit from the detector (100), at least one gas mixing area (5) for mixing the gas sent from the column inlet (2) and preferably N2 gas sent from the gas inlet (3), at least one radioactive measurement chamber (13), at least one gas inlet line (6) for transferring the gas to said radioactive measurement chamber (13), at least one radioactive or non-radioactive light emitting source (9), preferably at least one shielding material (10) that prevents gases from exiting the shielding area, at least one gas outlet line (11) for the gas to exit from said radioactive measurement chamber (13), at least one outlet chamber (14) preferably to allow the gas to exit, at least one scintillator crystal (7) over which the electrical signal is formed with the current applied by the first power source (17) and which interacts with the gases which are mixed in the said measurement chamber (13), wherein the scintillator crystal allows the formation of an optical signal by emitting photons which have specific emission wavelengths as a result of the gases with which it interacts and of the current applied to the photodetector (19) unit, or without the application of current, has an uncoated outer surface or is coated with a conductive coating (8), the outer surface of which has a predetermined thickness in addition to the optical signal for obtaining the electrical signal, preventing the corrosion which will occur thereon and separating the signal of low energy electrons from the optical signal, and at least one fixing apparatus (12) that carries the data of the light coming from the fiber optic cable inside said scintillator crystal (7) or with said photodetector (19) placed on the surface thereof, fixes the scintillator crystal (7) and transfers the electrical data from the scintillator crystal (7) to the data output line (1).
Radiopharmaceutical production system and quality control system utilizing high performance liquid chromatography
HPLC-based quality control systems to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs.
Radiopharmaceutical Production System and Quality Control System Utilizing High Performance Liquid Chromatography
HPLC-based quality control systems to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs.