The current invention relates to the device and method to separate biological entities from a sample fluid by a microfluidic device. The claimed methods separate biological entities by differentiating the sizes of the biological entities with ultrasound modes. The claimed methods further utilize a multi-staged design that removes smaller size entities at earlier and wider sections and concentrates larger entities at later and narrower sections of a microfluidic channel.

Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance. An automatic analyzer (1) includes: a reaction container disk (120) that holds a reaction container (116); a stirring mechanism (124) that stirs liquid contained in the reaction container (116) in a non-contact manner; a carrying mechanism (125) that carries the reaction container (116) between the reaction container disk (120) and the stirring mechanism (124); a reagent disk (122) that holds a reagent container (121); and a reagent dispensing mechanism (123) that suctions and discharges a reagent contained in the reagent container (121), the stirring mechanism (124) is provided at a position where the reagent dispensing mechanism (123) discharges the reagent, and the reagent dispensing mechanism (123) discharges the reagent, which is sucked from the reagent container (121), to the reaction container (116) installed in the stirring mechanism (124).

An example system may be used to automate one or more processes relating to drill cutting handling, cleaning, and packing to produce consistently high-quality cleaned samples. In some implementations, an example system may employ cleaning processes including centrifugal and ultrasonic processes to clean a sample automatically without the aid of a human operator thereby increasing efficiency and quality of the produced samples for better subsequent sample analysis. A system may include an unloading module, a cleaning module, and packing module, all of which may be operated in combination with a robotic arm.

The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.

A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.

The current invention relates to the method and apparatus to magnetically separate biological entities with magnetic labels from a fluid sample. The claimed methods separate biological entities with magnetic labels by using a magnetic device. The claimed methods further include processes to dissociate biological entities magnetic conglomerate after magnetic separation.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

The current invention relates to the device and method to separate biological entities from a sample fluid by a microfluidic device. The claimed methods separate biological entities by differentiating the sizes of the biological entities with ultrasound modes. The claimed methods further utilize a multi-staged design that removes smaller size entities at earlier and wider sections and concentrates larger entities at later and narrower sections of a microfluidic channel.

The current invention relates to the method and apparatus to separate biological entities from a fluid sample. The claimed methods separate biological entities based on size of entities by using acoustic pressure nodes in a microfluidic device. The claimed methods further separate biological entities with magnetic labels and by using a magnetic device. The claimed methods further include combination of microfluidic devices and magnetic devices to separate biological entities from a fluid sample.

The current invention relates to the method and apparatus to magnetically separate biological entities with magnetic labels from a fluid sample. The claimed methods separate biological entities with magnetic labels by using a magnetic device. The claimed methods further include processes to dissociate biological entities magnetic conglomerate after magnetic separation.