A computer implemented method to allocate control samples for validating a diagnostic test within a laboratory system is provided. The laboratory system comprises a storage, a transport system, and at least two analyzers. A total number of control sample aliquots and an aliquot volume for each control sample aliquot is determined based on a validation time schedule. Information is presented for distributing the total control sample volume into the determined total number of control sample aliquots with the determined aliquot volumes. Information is also presented for distributing the control sample aliquots to one or more of the at least two analyzers according to the validation time schedule.

Methods and systems for sensing headspace vial presence are described herein. In one embodiment, a system can include a sample probe, a fluid source in fluid communication with the sample probe, one or more of a pressure sensor and a flow sensor in fluid communication with the sample probe, and a processor configured to: (a) receive a first set of signals from the one or more of the pressure and flow sensors, execute an ejection procedure to remove a sample vial from the sample probe, receive a second set of signals from the one or more of the pressure sensor and the flow sensor during step (b), (d) detect whether the ejection procedure is successful from the first set of signals and the second set of signals, and (e) in response to the detecting, initiate one or more actions selected from the group consisting of: a remediation and an alert.

Aspects of the present disclosure include methods for integrating data quality assessment with data acquisition with a flow cytometer. Methods according to certain embodiments include detecting light with a light detection system from a sample irradiated by a light source in a flow stream, generating event data signals in response to events detected with the light detection system, binning the generated event data signals in a plurality of binning windows having overlapping data bins and assessing the plurality of binning windows for outlier events in the generated data signals. Systems having a processor with memory having instructions for practicing the subject methods are also described. Non-transitory computer readable storage medium is also provided.

When the automatic analyzer is installed in an environment with a high altitude and different external atmospheric pressures, there is a problem that an amount of vacuum suction decreases due to a decrease in suction performance of a vacuum pump and it is difficult to perform vacuum suction of an analyzed reaction liquid. In view of the above, by newly providing a pressure adjustment mechanism within a flow path connecting a vacuum tank to vacuum pump, it possible to control the pressure difference between a pressure in the vacuum tank and an external atmospheric pressure where the analyzer is installed to be constant regardless of the installation environment. Additionally, by providing a hole in communication with the outside in the vacuum tank or a vacuum bin, it possible to control the pressure difference between the pressure in the vacuum tank and the external atmospheric pressure where the analyzer is installed to be constant regardless of the installation environment.

Provided is an automatic analysis device that shortens the confirmation time for calibration or precision management. This automatic analysis system includes an analysis device configured to perform an analysis for deriving a property of a specimen on the basis of the relative relationship between a measured value of a standard specimen for which the property is known and a measured value of the specimen, and a display device that displays information about calibration or precision management carried out on the analysis device using the standard specimen, the system being characterized in that the display device displays: a request list including request information about request for the calibration and/or the precision management; and/or a preparation list that displays, in an empty manner, a field of the standard specimen that corresponds to an in-rack position number where the standard sample is not to be placed, as preparation information about preparation of the standard specimen to be used, in accordance with the request, in the calibration and/or the precision management.

A system and method for calibration of analytical instruments includes a software application allowing users to compute, construct, display, review, select and evaluate initial calibration models. The software application summarizes the initial calibration using the method evaluation parameters and the user selected evaluation criteria in the initial calibration evaluation table. The software application is a mathematically based program that will independently compute, construct, and display the initial calibration for each target analyte. This program then uses logic functions to review and select calibration variables against evaluation parameters. The software application is a user friendly tool performing all of the calculations independent of the on-boarded software and displays that information on a novel data visualization platform. The software application is the answer to questions centering around software limitations users encounter with on-board instrument software.

The method for generating an index for managing the analytical accuracy of a sample analyzer includes a step of acquiring a determination result related to whether a sample is positive or negative from a plurality of sample analyzers, and a step of generating an index based on a ratio of a sample determined to be positive or negative by the plurality of sample analyzers from a plurality of determination results obtained from the plurality of sample analyzers.

Provided is an automatic analysis device that estimates causes of change in measurement values of a quality-control substance. An automatic analysis device that analyzes specimens includes an acquisition unit that acquires amount of change in measurement values of a quality-control substance used for quality control, a calculation unit that calculates a change prediction amount on the basis of a difference value in concentration values of a standard solution used for calibration before and after changing lots, and an estimation unit that estimates causes of change occurring in measurement values of the quality-control substance on the basis of results of comparing the amount of change and the change prediction amount.

A water quality management method for performing at least one of a quantitative analysis and a qualitative analysis of fine particles contained in water to be analyzed that includes connecting a filtration device provided with a fine particle capturing membrane for capturing fine particles to a flow pipe through which the water to be analyzed flows, allowing the water to be analyzed to flow from the flow pipe and through the fine particle capturing membrane attached to the filtration device for a predetermined period of time to capture fine particles contained in the water to be analyzed to form a fine particle capturing membrane sample, and performing at least one of a quantitative analysis and a qualitative analysis of the fine particle capturing membrane sample of a target water flow period at an arbitrary timing.

A maintenance method in an automatic analysis apparatus includes: a recognition step of recognizing an integrated rack 301A, 301B, 301C mounted with a cleaning solution container containing a cleaning solution, and a calibrator container containing a calibrator or a QC specimen container containing a QC specimen containing a sample having a known concentration; a cleaning solution supply step of aspirating a cleaning solution; and a supply step of aspirating the calibrator or aspirating the QC specimen, in which the cleaning solution supply step and the supply step are continuously performed from the cleaning solution container and the calibrator container or the QC specimen container mounted on the integrated rack 301A, 301B, 301C. Accordingly, an automatic analysis apparatus and a maintenance method in the automatic analysis apparatus that can reduce a burden on a user in calibration and the like during maintenance are provided.