The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.

In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

Embodiments of a dispenser and a dispensing method for an analyzer are disclosed herein. The dispenser can include a first structure containing a first fluid path and a probe containing a second fluid path. The first structure can include a heat source that can heat the first structure and a fluid contained in the first structure. The first structure can be physically and thermally connected to the probe such that the probe is indirectly heated by the heat source via thermal energy transferred through the first structure. The heat source can be controlled to heat the first structure to a first desired temperature and/or temperature range, which can result in the heating of the probe and the fluid contained in the probe to a second desired temperature and/or temperature range.

The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.

Disclosed is an automatic specimen feeding system and a control method therefor. The automatic specimen feeding system includes a main frame installed adjacent to a carbon measuring apparatus, having a space with an open upper portion; a specimen seating unit which reciprocates horizontally in a direction perpendicular to the carbon measuring apparatus while moving up and down with respect to the main frame, and on which a plurality of specimens can be seated; a specimen lift unit which is installed under the specimen seating unit and can lift one of the plurality of specimens seated on the specimen seating unit; and a specimen input unit which is installed lengthways in the direction towards the carbon measuring apparatus to grip specimens lifted by the specimen lift unit and to input the specimens into the carbon measuring apparatus.

Disclosed is a method for determining a starting amount of a first substance which is required for providing a predeterminable number of samples in a liquid handling process. Also disclosed is a corresponding computer program and a corresponding computer program product. The liquid handling process is described through at least one work step, taking into account at least one secondary condition. An estimated value for the starting amount of the first substance is determined. A simulation of the at least one work step is then performed. A new estimated value for the starting amount is determined and the simulation is repeated if the prior simulation could not be completed or an actual value ascertained in the simulation deviates from the estimated value by more than a predeterminable tolerance. Otherwise, the actual value ascertained on the basis of the simulation is the starting amount of the first substance.

A pipette assembly configured to aspirate liquid from a well having a cover includes: a pipette including a terminal end; a pipette tip detachably coupled to the terminal end; and a vibration inducer configured to vibrate the pipette tip when at least a portion of the pipette tip is located in the well thus reducing stiction between the cover and the pipette tip. This minimizes the pipette tip from getting detached from the pipette and stuck in the cover. Other systems and methods including vibrating a pipette tip are disclosed.

A system may include a horizontal actuator to move a tray, to which a microwell plate and a microfluidic chip may be coupled. The system may include a vertical actuator to move a support arm, to which a plurality of pipettes or pipette tips may be coupled. The system may include a rotational actuator to move an angle bracket, to which a magnet may be coupled. The system may include a heater, through which the pipettes may extend. The system may include a pump to control the flow of fluids through the pipettes. Disclosed methods include performing PCR within the described system.

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

The present disclosure provides a gate system for sample detection and a method of sample inspection, which relate to the field of detection and analysis technology. The gate system comprises: an accommodating apparatus configured to accommodate an inserted ticket to be detected; a wipe sampling apparatus including a wipe sampling belt which is configured to drive the ticket to be detected to move within the accommodating apparatus and to conduct a wipe sampling to the ticket; an inspiratory sampling apparatus configured to collect samples dropped from the wipe sampling apparatus; and a detection apparatus configured to detect the samples and output detection results. The gate system for sample detection and the method of sample inspection provided by the present disclosure have a wide range of applications and can perform rapid sampling and detection to those substances that are difficult to be volatilized.