The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Disclosed is a peroral endoscopic apparatus of a swallowable type, the peroral endoscopic apparatus including: at least one imaging unit configured to perform imaging of a human body digestive system and output image data; at least one ultrasonic unit configured to output ultrasonic data on a submucosal region of the digestive system and a peripheral organ located therearound; a magnetic unit configured to adjust a position, a posture, and a proceeding direction of the peroral endoscopic apparatus in response to an external magnetic force; a transceiving unit configured to transmit the image data and the ultrasonic data to an external device or receive an external control signal; a control unit configured to control the imaging unit and the ultrasonic unit to perform imaging of the digestive system and the submucosal region simultaneously or individually; and a power supply unit configured to supply power.

Fluorescence imaging with reduced fixed pattern noise is disclosed. A method includes actuating an emitter to emit a plurality of pulses of electromagnetic radiation and sensing reflected electromagnetic radiation resulting from the plurality of pulses of electromagnetic radiation with a pixel array of an image sensor to generate a plurality of exposure frames. The method includes applying edge enhancement to edges within an exposure frame of the plurality of exposure frames. The method is such that at least a portion of the plurality of pulses of electromagnetic radiation emitted by the emitter comprises one or more of electromagnetic radiation having a wavelength from about 770 nm to about 790 nm.

An endoscope apparatus includes a compression processing control unit configured to carry out a compression processing of compressing image data by using a compression parameter to generate compressed data, a monitor that is a display unit configured to display a display image corresponding to the image data, an information quantity detection unit configured to detect a quantity of information on an object contained in the image data, and a judgement unit configured to carry out a judgement processing of judging whether or not a judgement value corresponding to the quantity of information is smaller than a predetermined threshold. The image pickup of the object and the generation of the image data are continuously performed multiple times, and the judgement processing is carried out whenever the image data is generated. The compression parameter and the display image are determined based on a result of the judgement processing.

An electronic endoscope processor includes a converting means for converting each piece of pixel data that is made up of n (n≥3) types of color components and constitutes a color image of a biological tissue in a body cavity into a piece of pixel data that is made up of m (m≥2) types of color components, m being smaller than n; an evaluation value calculating means for calculating, for each pixel of the color image, an evaluation value related to a target illness based on the converted pieces of pixel data that are made up of m types of color components; and a lesion index calculating means for calculating a lesion index for each of a plurality of types of lesions related to the target illness based on the evaluation values calculated for the pixels of the color image.

The present disclosure provides methods, computing device readable medium, devices, and systems that utilize a cheek retractor and/or a mobile device holder for case assessment and/or dental treatments. One cheek retractor includes a first and a second lip holder, both including imaging markers of a predetermined size to determine a scale of teeth of a user, where each imaging marker is located a predefined distance from the remaining imaging markers, and where the lip holder is to hold a cheek away from a mouth of a user to expose teeth of the user. A mobile device holder can include elements to receive a mobile device to capture images of the patient's teeth.

Embodiments of a hybrid imaging sensor that optimizes a pixel array area on a substrate using a stacking scheme for placement of related circuitry with minimal vertical interconnects between stacked substrates and associated features are disclosed. Embodiments of maximized pixel array size/die size (area optimization) are disclosed, and an optimized imaging sensor providing improved image quality, improved functionality, and improved form factors for specific applications common to the industry of digital imaging are also disclosed.

An endoscope device includes: an normal light image acquisition unit that acquires an normal light image; a special light image acquisition unit that acquires a special light image; a blended image generation unit that generates a blend image by combining one color component image from among a plurality of color component images constituting the normal light image and the special light image; and a superimposed image generation unit that generates a color superimposed image by combining the blended image with another color component image. The blended image generation unit generates the blended image by replacing a part of the pixels of the one color component image with the corresponding pixels of the special light image such that they are blended in a substantially uniform distribution over the entire blended image.

An apparatus for measuring a scanning pattern of an optical scanning apparatus can easily reduce the effect of stray light and improve the measurement accuracy of the scanning pattern. An apparatus for measuring a scanning pattern of an optical scanning apparatus (100), which scans an object being illuminated with illumination light and generates a display image of the object being illuminated, includes a screen (11) scanned by the illumination light and an optical position detector (12) that detects the position of an irradiation spot of the illumination light on the screen (11). The apparatus for measuring a scanning pattern sequentially detects a position of the irradiation spot at predetermined time points with the optical position detector (12) during scanning of the screen (11) to measure the scanning pattern of the illumination light.

A scanning observation apparatus (10) deflects illumination light with an actuator (25) through an illumination optical system (26) to scan an object (32), subjects light from the object (32) to photoelectric conversion with an optical detector (44), performs processing with an image processor (46), and displays an image of the object (32) on a display (60). A memory (35) stores information on optical characteristics related to chromatic aberration of magnification of the illumination optical system (26) relative to light of predetermined colors. A scanning pattern calculator (45) calculates a scanning pattern, on the object (32), of light of each color using the information. Using the scanning pattern, the image processor (46) calibrates a plot position yielded by a photoelectric conversion signal from the optical detector (44) for light of each color and generates an image of the object (32), thereby more easily correcting the chromatic aberration of magnification.