Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research. This disclosure describes technology and various embodiments of a system and method for imaging blood vessels and the intra-vessel blood flow, using at least laser speckle contrast imaging, with high speed so as to provide a rapid estimate of vessel-related or blood flow-related parameters.

A fundus camera displays guide information on a display panel which can be viewed by a testee to guide the testee to adjust a relative position of the fundus camera and a tested eyeball of the testee to a determined position. Therefore, the testee can use the above-mentioned fundus camera to self-shoot fundus images with better image quality. A method for self-shooting fundus is also disclosed.

A multifunctional medical optical examination instrument including a hand-holdable portion, at least an optical examination head portion mountable on the hand-holdable portion and including at least optical examination and non-digitized viewing optics and image digitization, storage and transmission circuitry included in at least one of the hand-holdable portion and the at least optical examination head portion, the image digitization, storage and transmission circuitry being arranged to receive an image from at least a portion of the at least optical examination and non-digitized viewing optics.

An eye-imaging apparatus and system is described including arrayed optical fibers having a high numerical aperture and circular fiber array ends arranged at skewed angles relative to the optical axis of the imaging path. Circular fiber array ends are arranged to emit the illumination light into an eye at a skewed angle and a light intensity distribution converter along the illumination path to convert a bell-shaped distribution into a top-hat distribution. As a result, illumination uniformity on the retina of the eye is improved.

A prism array light redistribution apparatus for an eye imaging system including light transmitting fibers, light receiving fibers, and a micro prism array optically coupled to bridge the light transmitting fibers and the light receiving fibers. The array may be further configured to receive light having a bell-shaped angular distribution from the light transmitting fibers and refract the received light to enter the light receiving fibers such that a square-shaped angular distribution of light emits from a light emitting end of the light receiving fibers.

An eye-imaging apparatus and system is described including circular fiber array ends arranged at skewed angles relative to the optical axis of the imaging path, a light intensity distribution converter along the illumination path to convert a bell-shaped distribution into a top-hat distribution, an image sensor, and high frequency response light source(s) operating in flash illumination mode in synchronization with the image sensor. As a result, unnecessary exposure of illumination light to a patient eye is minimized while the illumination light can span a wide enough coverage range with desired intensity and spectral distribution to cover the desired angular field of view and spectral range on a retina.

An adaptor (100) which may be attached to a portable image capturing device (19) and a method of capturing images of a retina (2) of an eye (1). The adaptor (100) may comprises an illumination unit (110), a beam splitter (130), an objective lens system (140) and a secondary lens system (150). The objective lens system (140) and the secondary lens system (150) share a first optical axis (160). By offsetting an output aperture (108) of the adaptor (100), or offsetting a camera of the image capturing device (19), from the first optical axis (160) and/or offsetting the illumination unit (110) from a second optical axis (170), overlap of imaging and illumination pathways in the eye (1) may be reduced or eliminated.

To provide a close-up imaging device whereby both imaging of an anterior eye and imaging of an eye ground can easily be performed by attaching the device to a mobile terminal such as a smartphone. The above-described problem is solved by a close-up imaging device (1B) detachably mounted to a mobile terminal (9) equipped with a light source (92) and a camera lens (91) for imaging, comprising a color filter member (97) detachably provided above the light source (92), and a convex lens member (93) detachably provided above the camera lens (91). Imaging, of an anterior eve is performed by removing the color filter member (97) and attaching the convex lens member (93), and observation of an injury of the anterior eye is performed by attaching the color filter member (97) and the convex lens member (93). The dose-up imaging device (1B) may further detachably comprise a slit light forming member that forms light from the light source (92) into slit light by a cylindrical lens, and a tubular member including a convex lens at a tip end thereof.

A prism array light redistribution apparatus for an eye imaging system including light transmitting fibers, light receiving fibers, and a micro prism array optically coupled to bridge the light transmitting fibers and the light receiving fibers, configured to receive light having a bell-shaped angular distribution from the light transmitting fibers and refract light emitted by the light transmitting fibers to enter the light receiving fibers.

Imaging various regions of the eye is important for both clinical diagnostic and treatment purposes as well as for scientific research. Diagnosis of a number of clinical conditions relies on imaging of the various tissues of the eye. The subject technology describes a method and apparatus for imaging of the back and/or front of the eye using multiple illumination modalities, which permits the collection of one or more of reflectance, spectroscopic, fluorescence, and laser speckle contrast images.