A system for multi-scale closed-loop eye tracking to compensate for translation and rotation motion while imaging in vivo a surface area of an internal structure of an eye of a subject includes a narrow field imaging device optically coupled to an optical path to receive light reflected from the surface area of the structure of the eye. A wide field camera is optically coupled to the optical path by a beam splitter disposed in the optical path. A tracking mirror is disposed in the optical path between the beam splitter and the structure of the eye. A control process algorithm actively compensates substantially in real time for both translational and rotational movements of the eye. A system where a torsional correction device causes a rotating movement of a subject's head and a method for multi-scale closed-loop eye tracking are also described.

A computer-implementable method of analyzing tissues of a retina. A polarization-sensitive (PS-OCT) image data set of the retina is received from a polarization-sensitive device, each element in the polarization-sensitive image data set being associated with an intensity value ({I.sub.1, . . . , I.sub.L}) and a polarization direction ({P.sub.1, . . . , P.sub.L}). A likelihood score is determined for each element of the polarization-sensitive image data set based on the intensity value of the element and a degree of divergence (μ*.sup.TP or D.sub.2) of the polarization direction associated with the element from a reference polarization direction (μ*) associated with the polarization sensitive image data set, wherein the likelihood score indicates whether said element is drawn from a directionally polarized distribution or a depolarizing distribution, Elements of the polarization-sensitive image data set are classified using the determined likelihood scores to analyze tissues of the retina.

A fundus analysis apparatus includes a storage, an area setting unit, and a morphological information generating unit. The storage is configured to store OCT information acquired by applying optical coherence tomography to the fundus of an eye. The area setting unit is configured to set a front area corresponding to a front surface of the lamina cribrosa and a rear area corresponding to a rear surface of the lamina cribrosa in the OCT information. The morphological information generating unit is configured to generate morphological information indicating the morphology of the lamina cribrosa based on at least the front area and the rear area.

Systems and methods for imaging tissue are described. Particularly, systems and methods of imaging an inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex of a patient's eye are disclosed. Imaging an inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex may include applying a stain to the inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex of the patient's eye, causing the stain to produce fluorescent light having a wavelength within a near-infrared range, capturing the fluorescent light, and producing an Optical Coherence Tomography (OCT) image of the inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex with an OCT imaging system that is configured to detect light within the near-infrared range.

The invention provides an apparatus and method for scanning, imaging and treating the retina of an eye. The apparatus (10) comprises a source of collimated light (14), a two-dimensional scanning device (16) having two axes of rotation (16a, 16b), wherein the axes of rotation (16a, 16b) are orthogonal and substantially planar, and wherein the source of collimated light (14) and the two-dimensional scanning device (16) combine to provide a two-dimensional collimated light scan from a point source (22). The apparatus (10) further comprises a scan transfer device (18), wherein the scan transfer device (18) has two foci (18a, 18b) and the point source (22) is provided at a first focus point (18a) of the scan transfer device (18) and an eye (12) is accommodated at a second focus point (18b) of the scan transfer device (18), and wherein the scan transfer device (18) transfers the two-dimensional collimated light scan from the point source (22) into the eye (12).

A fundus photography device includes: an OCT optical system configured to detect interference between a measurement light from a fundus of a subject's eye and a reference light from a reference optical path; a fundus photography optical system configured to detect a reflected light from the fundus; a controller configured to generate a tomographic image of the fundus and a first front image of the fundus based on an output signal from the OCT optical system, and generate a second front image of the fundus based on an output signal from the fundus photography optical system. The controller is configured to cause simultaneous display of the first front image and the second front image in different display regions on a monitor.

An apparatus for parallel optical coherence tomographic funduscope includes an illumination arm, a processing unit, and a retina imaging interferometer. The illumination arm includes a light source used for emitting incident lights; the processing unit is used for processing raw images from the retina imaging interferometer to obtain fundus images; and the retina imaging interferometer which includes a sample arm, a reference arm, a detection arm and a blocking unit to block unwanted back reflections from optical elements and eye, is used for acquiring the raw images by a camera in the detection arm. The illumination and the reference arms are located in a first light path and the sample and the detection arms are located in a second light path. The blocking unit include a detection pupil located at the intersection of the first and second light paths to block unwanted back reflections from optical elements and eye.

Disclosed is a method for analyzing retinal image data obtained using spectral-domain optical coherence tomography (SD-OCT). The image data comprise a cross-section of the retina and an en face image of the retina of a subject having AMD (age-related macular degeneration). The image data are processed to obtain an accurate structure showing locations, shape, size, and other data on drusen (deposits under the retina). This structural information is processed to extract quantitative drusen features that are indicative of a risk of progression of AMD from the dry form to the wet form of the disease in a given subject and defined time period, including short time intervals (one year or less). Relevant drusen features used include number, en face area and volume of drusen detected; shape of drusen detected; density of drusen; and reflectivity of drusen. The method uses the extracted drusen features in combination with clinical data and measurement of the changes of the quantitative image features over time to derive a risk score for whether or not the subject will progress from dry AMD to wet AMD in a defined time period.

An optical coherence tomography includes a light source, a light separator, a light generator configured to generate interference light, a detector configured to detect the interference light, a first optical element, and at least one of second optical elements comprising a pair of surfaces, and performs forming a tomographic image of a subject. The first optical element is arranged on a measurement light path so as to be closest to the subject, and satisfies at least one of following conditional formulas:

−(W−S)<U−2Z<X−W;   [a2]

U−2Z<−W; and   [b1]

U−2Z>X−W+S,   [c2] W: a predetermined operation distance U: a depth of interest S: a range of interest X: a distance which is greater than W+U+S and minimal among distance(s) between the pair of surfaces Z: a shallowest position of the area of interest relative to an origin position.

Provided is an ophthalmologic apparatus, including: a scan unit configured to repeat two-dimensional scanning on a fundus of an eye to be inspected with measuring light; an image generation unit configured to generate a two-dimensional image of the fundus based on reflected light of the measuring light from the fundus that is two-dimensionally scanned; and a control unit configured to control, in the two-dimensional scanning, an amount of the measuring light that is radiated to the fundus and is not used to generate the two-dimensional image to be smaller than an amount of the measuring light that is radiated to the fundus and is used to generate the two-dimensional image.