Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

A low coherence imaging method comprises acquiring image data of an object with an interferometric imaging system, where the image data is from a location of the object at first and second times; determining a first depth profile from the image data from the location at the first time and a second depth profile from the image data of the location at the second time; determining a change with respect to depth between the first and second depth profiles; and determining a property, or identifying a location, of at least one dynamic particle in the object based on the change between the first and second depth profiles. The method is able to identify, analyze, and/or visualize dynamic particles with features comparable to at least fluorescein angiography, indocyanine green angiography, confocal scanning laser fluorescein angiography, confocal scanning laser indocyanine green angiography, and fluorescence microscopy images, without the use of a dye.

A processor acquires a first fundus image of an examined eye including a foreground area and a background area other than the foreground area. The processor also generate a second fundus image by performing background processing to replace a first pixel value of a pixel configuring the background area with a second pixel value different from the first pixel value.

An ophthalmologic apparatus of an embodiment example includes a front image acquiring device, a first search processor, and a second search processor. The front image acquiring device is configured to acquire a front image of a fundus of a subject's eye. The first search processor is configured to search for an interested region corresponding to an interested site of the fundus based on a brightness variation in the front image. The second search processor is configured to search for the interested region by template matching between the front image and a template image in the event that the interested region has not been detected by the first search processor.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user’s body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

The present disclosure relates to methods and systems for quantifying the vascular pattern using ocular imaging that shows vessel profiles for the detection, prevention, and treatment of diabetic retinopathy and other related ocular vascular diseases.

An ophthalmologic apparatus of an embodiment example includes a front image acquiring device, a first search processor, and a second search processor. The front image acquiring device is configured to acquire a front image of a fundus of a subject's eye. The first search processor is configured to search for an interested region corresponding to an interested site of the fundus based on a brightness variation in the front image. The second search processor is configured to search for the interested region by template matching between the front image and a template image in the event that the interested region has not been detected by the first search processor.

Disclosed herein include methods, kits, formulations, and compositions for increasing choroidal or retinal perfusion or promoting non-leaking or minimally-leaking choroidal or retinal revascularization in a subject in need thereof. An effective amount of an angiogenesis factor (e.g., a pro-angiogenic factor and/or a vascular maturation factor) can be administered to the subject.

Imaging various regions of the eye is important for both clinical diagnostic and treatment purposes as well as for scientific research. Diagnosis of a number of clinical conditions relies on imaging of the various tissues of the eye. The subject technology describes a method and apparatus for imaging of the back and/or front of the eye using multiple illumination modalities, which permits the collection of one or more of reflectance, spectroscopic, fluorescence, and laser speckle contrast images.

The invention relates to an arrangement 10 with an OCT device 20 for scanning an object region volume 22 arranged in an object region 18 with an OCT scanning beam 21, comprising an item 24 which has a section 84 that is arrangeable in the object region 18 and is localizable in the object region volume 22 by means of the OCT device 20, and having a computing unit 60 connected to the OCT device 20 and having a computer program for determining a 3-D reconstruction of the object region volume 22 and determining the location of the portion of the object 24 in the object region volume 22 by processing OCT scan information obtained with the OCT device 20 by scanning the object region volume 22. According to the invention, the computer program has a calculation routine for determining a target area in the 3-D reconstruction of the object region volume 22, which routine determines a reference variable for the object 24 for the target area. The computer program contains a path planning routine that uses a criterion to calculate an optimal path for object 24 to the target spatial position, the criterion being a shadow measure that quantifies the occurrence of shadows caused by object 24 in the calculated 3-D reconstruction. The invention also relates to a computer program and a method for determining a 3-D reconstruction of an object region volume 22 in an object region 18.